Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
K KempfC Vollmert

Abstract

Vaspin has recently been identified as novel adipokine with high expression in adipose tissue of obese and type 2 diabetic subjects and with potentially insulin-sensitising properties. However, the impact of vaspin gene variants on the risk of type 2 diabetes mellitus (T2DM) has not been determined yet. Therefore, the aim of our study was to investigate the association of vaspin single nucleotide polymorphisms (SNPs) with T2DM and obesity. We analysed the association between 25 vaspin SNPs and T2DM in initially healthy 35-84 year-old individuals of the population-based, cross-sectional German KORA F3 study and assessed the association with measures of obesity. Genotyping was carried out with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry of allele-dependent primer extension products and associations with T2DM and obesity were analysed by logistic regression analysis. Our results demonstrate a significant association of vaspin SNP rs2236242 with T2DM in the KORA F3 study with the AA genotype bearing an increased risk (adjusted OR 2.35 [1.59; 3.46] versus AT/TT). This association appears to be independent of obesity. Our finding corroborates previous studies that suggested a link between the novel ad...Continue Reading

Citations

Oct 10, 2009·European Journal of Applied Physiology·Jin-Kyung ChoHyun-Sik Kang
Jun 10, 2009·Obesity Surgery·Ammon HandisuryaAlexandra Kautzky-Willer
Nov 20, 2012·Journal of Lipid Research·Daniel S KimGail P Jarvik
Jan 24, 2013·PloS One·Jana BreitfeldYvonne Böttcher
Aug 26, 2014·Diabetes Research and Clinical Practice·Rennan FengChanghao Sun
Jun 13, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jana BreitfeldPeter Kovacs
May 10, 2013·Molecular Biology Reports·Xinsheng LaiHong Chen
Sep 29, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Zeynep GinisTuncay Delibasi
May 20, 2011·Annales d'endocrinologie·D GauvreauK Cianflone
May 7, 2015·BioMed Research International·Rumyana Dimova, Tsvetalina Tankova
Nov 6, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hai Ling LiYa Wei Xu
Aug 22, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J BreitfeldM Stumvoll
Sep 17, 2019·Balkan Journal of Medical Genetics : BJMG·E SuligaS Głuszek
Dec 18, 2015·Journal of Diabetes·Rongfeng DaiYan Han
Jan 10, 2019·International Journal of Molecular Sciences·Radzisław MierzyńskiBożena Leszczyńska-Gorzelak
Dec 15, 2016·Turkish Journal of Medical Sciences·Amina AlnoryOlfat Shaker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.