Vav2 protein overexpression marks and may predict the aggressive subtype of ductal carcinoma in situ

Biomarker Research
YunQing JiangMarina A Guvakova

Abstract

A subset of patients with ductal carcinoma in situ (DCIS) will develop invasive breast cancer (IBC). To date, there are no effective predictive biomarkers for identifying this subset with worse prognosis whose lesions are essentially indistinguishable histologically from those with favorable outcomes. We hypothesized that measurable parameters that discriminate DCIS from DCIS with concurrent invasion may serve as diagnostic biomarkers (BM) of progressive cancer in situ (CIS). Using a novel imaging-based method of tissue testing, we measured the relative expression levels of three candidate BM proteins specifically implicated in IBC progression - the insulin-like growth factor I receptor (IGF-IR), Ras-related protein 1 (Rap1), and Vav2 oncoprotein. Protein profiles were compared in 42 histologically normal mammary epithelial samples, 71 CIS (35 without/36 with invasion either on diagnostic biopsy or final surgical excision), and 98 IBC of known estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status. The levels of the IGF-IR and Rap1 protein expression were significantly elevated in ER-positive (ER+/PR+/-/HER2 -) DCIS relative to normal epithelium (P <0.0001). The IGF-IR prot...Continue Reading

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Citations

Feb 15, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wedad M HannaSharon Nofech-Mozes
Sep 7, 2017·BMC Genomics·Mario BaumgartAlessandro Cellerino
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Apr 24, 2020·Frontiers in Cell and Developmental Biology·Maria Del Mar MaldonadoSuranganie Dharmawardhane
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bi-Bo TanNan Jia
Jul 20, 2020·Breast Cancer Research and Treatment·Marina A GuvakovaPaul J Zhang
Dec 2, 2017·International Journal of Cancer. Journal International Du Cancer·Daniel ReimerAlain G Zeimet
May 23, 2019·Cancer Research·Indira PrabakaranMarina A Guvakova

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Methods Mentioned

BETA
biopsy
GTPase
nucleotide
GTPases

Software Mentioned

SAS

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Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.