Vav3 is regulated during the cell cycle and effects cell division

Proceedings of the National Academy of Sciences of the United States of America
Keiko FujikawaWojciech Swat

Abstract

Vav3 is a member of the family of guanine nucleotide exchange factors implicated in the regulation of Rho GTPases. Although the exact in vivo function of Vav3 is unknown, evidence from several studies indicates a role distinct from Vav2 or Vav1. Here we report that the expression of Vav3 is regulated during the cell cycle. Strikingly, Vav3 was transiently up-regulated in HeLa cells during mitosis, whereas enforced expression of Vav3 perturbed cytokinesis and led to the appearance of multinucleated cells. These effects of Vav3 were RhoA-dependent, required phosphorylation of the regulatory tyrosine 173, but were not enhanced by N-terminal truncations. Thus, this report establishes that expression of Vav3 is strictly regulated in a cell cycle-dependent manner and implicates Vav3 in the control of cytokinesis.

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Citations

Jun 6, 2003·Current Opinion in Immunology·Ana V MileticWojciech Swat
Jun 3, 2014·Breast Cancer Research : BCR·Helena AguilarMiguel Angel Pujana
Nov 12, 2003·The Journal of Cell Biology·Ling SuSarah J Parsons
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Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·S M AminJ Guitart
Jan 29, 2010·Nature Reviews. Neuroscience·Luciano Conti, Elena Cattaneo
Sep 16, 2006·The Journal of Biological Chemistry·Martin P PlayfordMichael D Schaller
Mar 11, 2003·The Journal of Biological Chemistry·Jacques-Emmanuel GuidottiChantal Desdouets
May 4, 2005·The Journal of Biological Chemistry·Elisabeth T BarfodSteven D Lidofsky

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