VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization

Scientific Reports
Yih-Huei UenKai-Yuan Lin

Abstract

Although colorectal cancer (CRC) is one of the most common malignancies worldwide, the current therapeutic approaches for advanced CRC are ineffective. In this study, we investigated the involvement of the VAV3 oncogene in tumor progression and in the prognosis of human CRC. The two patient cohorts in this study comprised 354 CRC cases from 1998 to 2005 with documented pathologic and clinical factors and clinical outcomes. VAV3 protein levels were significantly correlated with the depth of invasion (P = 0.0259), the nodal status (P < 0.0001), distant metastasis (P = 0.0354), the stage (P < 0.0001), and poor disease-free survival (P = 0.003). Multivariate Cox regression analysis showed that VAV3 overexpression is an independent prognostic marker for CRC (P = 0.041). In vitro experiments indicated that VAV3 knockdown inhibited CRC cell growth, spread, and xenograft proliferation. Mechanistic studies further revealed that VAV3 overexpression could dysregulate the expression of cell cycle control- and metastasis-related molecules by activating the PI3K-AKT signaling pathway in both CRC cells and xenografts. This study suggests that VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV...Continue Reading

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Citations

Oct 11, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Chan LinYung-Chang Lin
May 4, 2018·Molecular Carcinogenesis·Rishi K JaiswalPramod K Yadava
Apr 24, 2020·Frontiers in Cell and Developmental Biology·Maria Del Mar MaldonadoSuranganie Dharmawardhane
Jul 23, 2021·Endocrine·Wanli RenYanxia Bai

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Methods Mentioned

BETA
xenograft
transfection
zymography
xenografts
GTPases
surgical resection
Assay

Software Mentioned

SPSS

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