Vbeta usage and T regulatory cells in children following partial or total thymectomy after open heart surgery in infancy

Scandinavian Journal of Immunology
J H EysteinsdottirH M Ogmundsdottir

Abstract

During open heart surgery in infants the thymus was usually removed, partly or completely. Our previous studies on 16 such children indicated reduced T-cell output later in life with signs of extrathymic maturation of the T cells, but no reduction in T regulatory cells (CD4+CD25+). The diversity of the T-cell repertoire in these children was examined to test if the extrathymic microenvironment could alter Vbeta usage. The expression of Foxp3 and CD127 in CD4+CD25(high) T cells was measured in order to determine whether the T regulatory cells had the phenotype of natural T regulatory cells. There was a wide distribution of Vbeta usage in both study and control groups. Significant variability was found in Vbeta usage for CD4+ and CD8+ T cells when the distribution of the percentage of T cells expressing each Vbeta family was analysed between individuals within each group (P < 0.001; Kruskal-Wallis). Significant difference was also found in average usage of Vbeta2, Vbeta5.1 and Vbeta14 chains within CD4+ T cells and Vbeta2, Vbeta8 and Vbeta21.3 chains within CD8+ cells between the groups (P < 0.05; Student's t-test). There was no difference between the two groups with regard to the proportion of CD4+CD25(high) T cells and no diffe...Continue Reading

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Citations

Apr 24, 2010·Médecine sciences : M/S·Delphine Sauce, Victor Appay
Oct 17, 2014·Interactive Cardiovascular and Thoracic Surgery·Jorg RoosenBart Meyns
Feb 6, 2017·Frontiers in Immunology·Susana L SilvaAna E Sousa
Dec 17, 2020·Pediatric Transplantation·Konstantinos MengrelisE Graham Davies
Jul 21, 2021·Pediatric Cardiology·Koichi Yuki, Sophia Koutsogiannaki

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