PMID: 11898001Mar 19, 2002Paper

Vbeta18.1(+) and V(alpha)2.3(+) T-cell subsets are associated with house dust mite allergy in human subjects

The Journal of Allergy and Clinical Immunology
Moritz F KircherKirsten Beyer

Abstract

The recognition of allergenic peptides by T cells through their T-cell receptor (TCR) represents a crucial step in the initiation of an allergen-specific immune response. In parallel to the superantigen-driven restricted expansion of Vbeta subsets in autoimmune and infectious diseases, reports in animals and human subjects have shown a similar capacity of classical antigens. The study was performed to analyze the V(alpha)/Vbeta expression in house dust mite (HDM) allergy. The TCR repertoire of 15 subjects with HDM allergy, 22 atopic subjects without HDM allergy, and 19 nonatopic individuals, members of 2 extended and 4 nuclear families, was determined. By using flow cytometry, the expression of 22 Vbeta and 3 V(alpha) elements was analyzed in vivo and after in vitro allergen stimulation. In comparison with nonatopic and atopic individuals without HDM allergy, freshly isolated PBMCs of individuals with HDM allergy showed a significantly higher frequency of Vbeta18(+) and V(alpha)2.3(+) T cells. Although members of all 3 groups had a similar lymphocyte proliferation response after in vitro stimulation with Der p 1 or Der p 1 peptide(101-131), a significant expansion of Vbeta18(+) and V(alpha)2.3(+) T cells in vitro occurred only ...Continue Reading

Citations

Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KinnunenT Virtanen
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E R JarmanJ R Lamb
Feb 9, 2011·Immunology and Cell Biology·John J MilesDavid A Price
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A AsturiasA Martínez
Sep 18, 2007·Immunologic Research·Wayne R Thomas, Belinda J Hales
Jun 28, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Tabita HünemeierJosé A B Chies

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