VBM sensitivity to localization and extent of mouse brain lesions: A simulation approach

Computer Methods and Programs in Biomedicine
Delfina BraggioIgnacio Larrabide

Abstract

Voxel-based morphometry (VBM) is a popular neuroimaging technique, used to detect and quantify morphological differences in brain tissues between groups. Widely used in human studies, VBM approaches have tremendous potential for neuroimaging studies in animal models. A significant challenge for applying VBM to small animal studies is the poor understanding of how the design of preprocessing pipelines impacts quantitative results. This is important because the large differences in size, resolution, and imaging parameters implies that human imaging preprocessing pipelines cannot be uncritically applied to small animal studies. In this work, we assessed and validated the performance of different VBM pipelines for the study of the mouse brain. We applied two pipelines -namely DARTEL VBM and Optimized VBM- by varying spatial normalization used during preprocessing. Using an automatic method, we simulated varying levels of volumetric gray matter (GM) loss and sizes of tissue atrophy on specific areas of the mouse brain. We evaluated the performance of each pipeline by comparing location and extent of the differences detected by them with the simulated ones. Finally, we applied both pipelines on magnetic resonance (MR) images of the b...Continue Reading

References

Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·E A MaguireC D Frith
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Aug 9, 2005·NeuroImage·X Josette ChenJeffrey T Henderson
May 13, 2006·IEEE Transactions on Medical Imaging·Bilge Karaçali, Christos Davatzikos
May 1, 2007·Magnetic Resonance Imaging·Shan ShenAnnette Sterr
Sep 1, 2007·NeuroImage·John Ashburner
Feb 7, 2012·NeuroImage·Lindsay S CahillR Mark Henkelman
Jul 10, 2013·Magnetic Resonance Imaging·Stephen J SawiakT Adrian Carpenter
Nov 14, 2013·The American Journal of Psychiatry·Stella J de WitOdile A van den Heuvel
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols
May 17, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans-Christian FritzMartin Lotze
May 17, 2014·Frontiers in Aging Neuroscience·Stephen J SawiakMarc Dhenain
Apr 10, 2018·Neuroscience·Jimena Barbeito-AndrésPaula N Gonzalez

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