Abstract
Upregulation of prolyl isomerase-1 (Pin1) protein expression and activity was associated with the pathogenesis of diabetic vasculopathy through induction of endothelial oxidative stress and inflammation. Moreover, VDR agonist protects against high glucose-induced endothelial apoptosis through the inhibition of oxidative stress. We aimed to explore the effects of the VDR agonist on diabetes-associated endothelial dysfunction and the role of Pin1 in this process. Streptozocin-induced diabetic mice were randomly treated with vehicle, VDR agonist (10 μg/kg/d, i.g., twice a week), or Pin1 inhibitor, Juglone (1 mg/kg/d, i.p., every other day), for eight weeks. In parallel, human umbilical vein endothelial cells (HUVECs) exposed to high-glucose condition were treated with 1,25-dihydroxyvitamin D3 and Juglone or vehicle for 72 hours. Organ chamber experiments were performed to assess endothelium-dependent relaxation to acetylcholine. Circulatory levels of Pin1, SOD, MDA, IL-1β, IL-6, and NO in diabetic mice, Pin1 protein expression and activity, subcellular distribution of p66Shc, and NF-κB p65 in high glucose-cultured HUVECs were determined. Both VDR agonist and Juglone significantly improved diabetes-associated endothelial dysfunctio...Continue Reading
References
Jun 13, 1997·Cell·R RanganathanJ P Noel
Oct 9, 1999·Free Radical Biology & Medicine·X DuP Rösen
Feb 14, 2007·Hypertension·Sergey DikalovDavid G Harrison
Jul 25, 2008·American Journal of Physiology. Cell Physiology·Tongzheng LiuDale G Hoyt
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Garry X Shen
Oct 20, 2010·Blood·Tarek BoussettaJamel El-Benna
Feb 12, 2011·Oxidative Medicine and Cellular Longevity·Igor Afanas'ev
Feb 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Yuen-Fung YiuHung-Fat Tse
Jun 21, 2011·Expert Reviews in Molecular Medicine·Tae Ho LeeKun Ping Lu
Aug 20, 2011·Trends in Biochemical Sciences·Yih-Cherng LiouKun Ping Lu
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Mark R HausslerAnthony W Norman
May 29, 2012·Cardiovascular Diabetology·Erik SalumJaak Kals
Dec 15, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michinori HirataMasafumi Fukagawa
Dec 19, 2012·Journal of Cardiovascular Translational Research·Lorella PolidoroC Ferri
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Akash SinhaTim Cheetham
Feb 15, 2013·American Journal of Nephrology·Keiji KonoShinichi Nishi
May 4, 2013·European Heart Journal·Francesco PaneniFrancesco Cosentino
Jun 26, 2013·American Journal of Nephrology·Ayelet GrupperIdit F Schwartz
Nov 29, 2013·Molecular Endocrinology·Olena AndrukhovaReinhold G Erben
Nov 29, 2013·The Journal of Clinical Endocrinology and Metabolism·F UbertiC Molinari
Jan 7, 2014·Genetics and Molecular Research : GMR·R B NingJ X Lin
Apr 16, 2014·BioMed Research International·Alessandra MagentaFabio Martelli
May 8, 2014·European Heart Journal·Francesco PaneniFrancesco Cosentino
Sep 10, 2014·Hypertension·Wei NiDavid G Gardner
Nov 20, 2015·International Journal of Cardiology·Sarah CostantinoFrancesco Cosentino
Dec 19, 2015·Physiological Reviews·Sylvia ChristakosGeert Carmeliet
Apr 9, 2016·International Journal of Cardiology·Jing-Zhang WangXiao-Hua Wang
Jun 15, 2016·Circulation·Cecilia C Low WangAllison B Goldfine
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J Berridge
Jul 19, 2016·Atherosclerosis·L M LinJ X Lin
Mar 17, 2017·International Journal of Molecular Sciences·Ming LiuJunbo Ge
Citations
Aug 3, 2019·Genetic Testing and Molecular Biomarkers·Na SongHao Zhang
Jun 6, 2019·Basic Research in Cardiology·Kerstin BoenglerRainer Schulz
Apr 10, 2019·Antioxidants·Taseer Ahmad, Yuichiro J Suzuki
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Yuansheng WuJinxiu Lin
Dec 2, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Long-Yan RanZhi-Zhong Guan
Jan 19, 2021·European Journal of Pharmacology·Hong XiangHongwei Lu