VE-cadherin and ACE: markers for sepsis in post mortem examination?

Legal Medicine
Annette M MüllerMichael Tsokos

Abstract

Altered expression of endothelial markers - especially adhesion molecules - is diagnostically helpful for diagnosis of ante mortal undiagnosed sepsis. Up to now it is unclear whether (1) expression of Angiotensin converting enzyme (ACE) and/or VE-cadherin (VEC) plays a comparable role, (2) whether expression intensity correlates with post mortem interval. Fifty-nine lung specimens (20 lung specimens with regular morphology from tumour lobectomies, 39 from patients who died of septic ARDS due to microbiologically proven Gram-negative sepsis) were stained with an antibody against ACE (1:80) resp. VEC (1:100). All specimens showed vessel type specific expression patterns for ACE and VEC which was dramatically reduced in sepsis. ACE staining intensity did not correlate with time between death and autopsy. VEC staining was slightly but statistically not significantly reduced with increasing time interval. Pulmonary VEC and ACE expression are reduced in septic ARDS. However, as neither ACE nor VEC expression correlates with time interval between death and post mortem, expression intensities of VEC or ACE are no reliable indices for time elapsed since death.

References

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Sep 19, 2002·The Journal of Pathology·Annette M MüllerC James Kirkpatrick
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Citations

Nov 2, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Samira BaumüllerAnnette M Müller
Oct 12, 2010·The Journal of International Medical Research·R-Y ZhangY-Q Tang
Nov 6, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A MaieseV Fineschi
Jun 11, 2019·International Journal of Immunopathology and Pharmacology·Raffaele La RussaVittorio Fineschi
Jul 11, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rosario Barranco, Francesco Ventura
Oct 31, 2019·Antibiotics·Lucia TattoliBiagio Solarino
Oct 24, 2020·Diagnostics·Chiara StassiElvira Ventura Spagnolo

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