Vectorcardiographic changes during cardioangiography with iodixanol and ioxaglate

International Journal of Cardiology
A Flinck, K Selin

Abstract

To compare the electrophysiological effects of two contrast media (CM), the non-ionic dimer iodixanol and the ionic dimer ioxaglate using computerised dynamic vectorcardiography (VCG) during coronary angiography. The study was designed as a double-blind, three-period crossover, randomised comparison between iodixanol (320 mg I/ml) and ioxaglate (320 mg I/ml). Group 1 (HVV) received ioxaglate (H) in the first injection in the left coronary artery (LCA) and iodixanol (V) in the following injections. Group 2 (VHH) received iodixanol in the first injection in LCA and ioxaglate in the following injections. The first three injections in the LCA were subjected to electrocardiographic analysis. For five out of six VCG variables, there was a significant difference in response between iodixanol and ioxaglate. For these five variables, the deviations from baseline were greater in the ioxaglate than in the iodixanol group (P<0.05). The most pronounced effects from ioxaglate were seen on the ST-segment and T-wave. Iodixanol caused less pronounced electrophysiological changes than ioxaglate, especially during the repolarisation phase. Vectorcardiography is a sensitive and reproducible technique for detecting electrophysiological effects indu...Continue Reading

References

Oct 26, 1990·The American Journal of Cardiology·J W Hirshfeld
Jan 1, 1990·Catheterization and Cardiovascular Diagnosis·J Missri, R M Jeresaty
Mar 1, 1989·Cardiovascular and Interventional Radiology·K LevorstadT Aakhus
Sep 5, 1989·The American Journal of Cardiology·P Dawson
Aug 1, 1968·Circulation·R ShabetaiW Hammill
Jul 1, 1967·Circulation·R F SmithC A Sanders

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