Vectorcardiographic QRS area is associated with long-term outcome after cardiac resynchronization therapy

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Kasper EmerekBrett D Atwater

Abstract

Recent studies have suggested that vectorcardiographic measures predict left ventricular (LV) reverse remodeling and clinical outcome in patients receiving cardiac resynchronization therapy (CRT). The objectives of this study were to compare predictive abilities of different vectorcardiographic measures (QRS area and sum absolute QRS-T integral) and transformation methods (Kors and inverse Dower) and to assess the independent association between the best predictor and outcomes in CRT recipients. This retrospective study included CRT recipients with a digital baseline electrocardiogram, QRS duration ≥120 ms, and ejection fraction ≤35%. The end point was a composite of heart transplantation, LV assist device implantation, or all-cause death. Analyses were performed for the overall cohort and for a prespecified subgroup of patients with left bundle branch block (LBBB). Of 705 included patients with a mean age of 66.6 ± 11.5 years, 492 (70%) were men, 374 (53%) had ischemic heart disease, and 465 (66%) had LBBB. QRS area from vectorcardiograms derived via the Kors transformation demonstrated the best predictive value. In multivariable Cox regression, patients with a smaller QRS area (≤ 95 μVs) had an increased hazard in the overall...Continue Reading

Citations

Mar 30, 2019·Circulation. Arrhythmia and Electrophysiology·Antonius M W van StipdonkKevin Vernooy
Sep 12, 2019·Pacing and Clinical Electrophysiology : PACE·Brett D AtwaterDaniel J Friedman
Dec 13, 2019·Current Treatment Options in Cardiovascular Medicine·Amit NoheriaG Joseph Orme
Apr 15, 2020·Pacing and Clinical Electrophysiology : PACE·Zak LoringBrett D Atwater
Jul 16, 2020·Journal of Cardiovascular Electrophysiology·Amrish DeshmukhPramod Deshmukh
Sep 10, 2020·Pacing and Clinical Electrophysiology : PACE·Christoffer PolcwiartekBrett D Atwater
Jun 17, 2020·Circulation. Arrhythmia and Electrophysiology·Albert K FeenyMina K Chung
Jan 22, 2021·Journal of Cardiovascular Electrophysiology·Mohammed A GhosseinKevin Vernooy
Feb 24, 2021·Scientific Reports·Katerina HnatkovaMarek Malik
Mar 7, 2021·Heart Failure Clinics·Giuseppe PalmieroVincenzo Russo
Nov 30, 2021·Circulation. Arrhythmia and Electrophysiology·Daniel J FriedmanBrett D Atwater

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