Vectorcardiography analysis of the repolarization response to pharmacologically induced autonomic nervous system modulation in healthy subjects

Journal of Applied Physiology
Farzad VahediLennart Bergfeldt

Abstract

Autonomic nervous system activity is essential for regulation of ventricular repolarization (VR) and plays an important role in several arrhythmogenic conditions. This study in 31 healthy adult subjects (16 men, 15 women) evaluated the VR response to pharmacologically modulated autonomic nervous system activity applying vectorcardiography (VCG) analysis. During continuous VCG recording, 0.01-0.1 μg·kg(-1)·min(-1) isoprenaline (Iso) was infused at an increasing flow rate until three targeted heart rates (HR) were reached. After Iso washout, one intravenous bolus of 0.04 mg/kg atropine was given followed by an intravenous bolus of 0.2 mg/kg propranolol. A 5-min steady-state VCG recording was analyzed for each of the seven phases (including baseline 1 and 2). Furthermore, during the first 4 min following atropine, six periods of 10-s VCG were selected for subanalysis to evaluate the time course of change. The analysis included QRS, QT, and T-peak to T-end intervals, measures of the QRS and T vectors and their relation, as well as T-loop morphology parameters. By increasing HR, Iso infusion decreased HR dependent parameters reflecting total heterogeneity of VR (T area) and action potential morphology (ventricular gradient). In cont...Continue Reading

References

Aug 1, 1976·American Heart Journal·J A Abildskov
Apr 1, 1970·Cardiovascular Research·A D Jose, D Collison
Nov 1, 1969·The Journal of Clinical Investigation·A D Jose, R R Taylor
Dec 1, 1983·Journal of the American College of Cardiology·D P Rardon, J C Bailey
Jan 1, 1983·IEEE Transactions on Bio-medical Engineering·D B Geselowitz
Aug 1, 1993·Circulation·P J SchwartzR S Crampton
Jul 8, 1998·Journal of Cardiovascular Electrophysiology·J A Larsen, A H Kadish
Jul 10, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kelley P Anderson
Jan 1, 1964·Circulation Research·J HAN, G K MOE
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Aigars RubulisLennart Bergfeldt
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Liliane WeckeLennart Bergfeldt
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Takuya YamazakiPaul Wang
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yunlong XiaShiwen Yuan
Jul 19, 2005·Progress in Biophysics and Molecular Biology·Chantal E Conrath, Tobias Opthof
Dec 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yunlong XiaShiwen Yuan
Sep 2, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Harmen H M DraismaCees A Swenne
Nov 25, 2006·The Journal of Clinical Investigation·Stefan WagnerLars S Maier
Mar 8, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tobias OpthofMichiel J Janse
Sep 11, 2007·Progress in Biophysics and Molecular Biology·Masanori KuzumotoSatoshi Matsuoka
Nov 13, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Liliane WeckeLennart Bergfeldt
Jun 17, 2008·Physiology·Luis F Couchonnal, Mark E Anderson
Sep 16, 2008·Journal of Electrocardiology·Prasad GuptaGan-Xin Yan
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Anders SahlénFrieder Braunschweig
Nov 4, 2009·Journal of Molecular and Cellular Cardiology·Michael Grimm, Joan Heller Brown
Dec 17, 2009·Journal of Electrocardiology·Ulla-Britt DiamantSteen M Jensen
Mar 1, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael GrimmJoan Heller Brown
Jul 19, 2011·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Farzad VahediLennart Bergfeldt

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Citations

May 21, 2015·Biomedizinische Technik. Biomedical Engineering·Muhammad A Hasan, Derek Abbott
May 7, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Farzad VahediLennart Bergfeldt
Mar 25, 2014·Biophysical Journal·Yuanfang XieDaisuke Sato
Aug 20, 2016·Journal of Electrocardiology·Jonathan W Waks, Larisa G Tereshchenko
Sep 21, 2013·Journal of Applied Physiology·Ulla-Britt DiamantLennart Bergfeldt
Feb 7, 2014·Medicine and Science in Sports and Exercise·Philip AagaardLennart Bergfeldt
Dec 4, 2014·Physiological Research·D PoulikakosM Malik

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