Vedolizumab Drug Level Correlation With Clinical Remission, Biomarker Normalization, and Mucosal Healing in Inflammatory Bowel Disease

Inflammatory Bowel Diseases
Badr Al-BawardyEdward V Loftus

Abstract

The clinical utility of vedolizumab (VDZ) trough levels (VTLs) in inflammatory bowel disease (IBD) is not well defined. The aims of this study are to determine the median VTLs and frequency of detected antibodies, the correlation of VTLs with C-reactive protein (CRP) and mucosal healing (MH), and the change in clinical management based on VTLs. A cross-sectional study of IBD patients treated with VDZ with VTLs checked between July 1, 2016, and March 1, 2017, was conducted. Mucosal healing was defined as absence of mucosal ulcers in Crohn's disease (CD) and Mayo endoscopic score ≤1 for ulcerative colitis (UC). Normal CRP was defined as ≤8 mg/L. A total of 171 patients (62% CD, 31% UC, 7% indeterminate colitis) were included. Median VTLs was 15.3 ug/mL (range, 0-60), and 1 patient had detectable antibodies to VDZ. Patients with a normal CRP had a median VTLs of 17.3 ug/mL vs 10.7 ug/mL in high CRP patients (P = 0.046). This was noted in CD (20.3 vs 10.4 ug/mL; P = 0.005) but not in UC patients (14.4 vs 20.8; P = 0.72). Mucosal healing was achieved in 35% of patients (37 of 105); among these, median VTLs was 13.7 ug/mL vs 16.1 ug/mL in patients who did not achieve MH (P = 0.64). Vedolizumab trough levels resulted in a change in cl...Continue Reading

References

Aug 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elana A MaserGordon R Greenberg
Sep 24, 2010·International Journal of Clinical Pharmacology and Therapeutics·Z H XuH Zhou
Apr 16, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·L Puig
Apr 21, 2012·European Journal of Gastroenterology & Hepatology·Francesc CasellasNatalia Borruel
Jul 31, 2012·Gut·Markus F Neurath, Simon P L Travis
Jan 23, 2013·European Journal of Gastroenterology & Hepatology·Mahesh BhalmeSimon Campbell
Apr 16, 2013·Inflammatory Bowel Diseases·Yi-Lin ChiuSusan K Paulson
Aug 24, 2013·The New England Journal of Medicine·Brian G FeaganUNKNOWN GEMINI 1 Study Group
Aug 24, 2013·The New England Journal of Medicine·William J SandbornUNKNOWN GEMINI 2 Study Group
Nov 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jean-Frédéric ColombelXavier Hébuterne
Nov 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bella UngarShomron Ben-Horin
Jan 20, 2016·Journal of Crohn's & Colitis·E ZittanM S Silverberg
May 21, 2016·Inflammatory Bowel Diseases·Andrew R ReininkPeter D R Higgins
Nov 29, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicolas WillietXavier Roblin
Aug 7, 2017·Gastroenterology·Joseph D FeuersteinUNKNOWN American Gastroenterological Association Institute Clinical Guidelines Committee
Oct 14, 2017·Alimentary Pharmacology & Therapeutics·N MitrevUNKNOWN IBD Sydney Organisation and the Australian Inflammatory Bowel Diseases Consensus Working Group
Dec 11, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bella UngarShomron Ben-Horin

❮ Previous
Next ❯

Citations

Apr 25, 2019·Current Gastroenterology Reports·Thomas X Lu, Russell D Cohen
Mar 22, 2019·Human Vaccines & Immunotherapeutics·Robert BattatNiels Vande Casteele
May 1, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Jimil ShahUsha Dutta
Nov 23, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Kendall W CradicMaria A V Willrich
Nov 23, 2019·Current Treatment Options in Gastroenterology·Saurabh Kapur, Stephen B Hanauer
Oct 28, 2019·Minerva gastroenterologica e dietologica·Daniela PuglieseAlessandro Armuzzi
Apr 12, 2019·Current Opinion in Gastroenterology·Konstantinos Papamichael, Adam S Cheifetz
Jun 24, 2020·Scandinavian Journal of Gastroenterology·Neil K SenguptaNeeraj Narula
Jul 9, 2020·Journal of Pediatric Gastroenterology and Nutrition·Martine A AardoomJohanna C Escher
Feb 7, 2020·Journal of Clinical Medicine·Patrizio ScarozzaGiovanni Monteleone
Jul 19, 2019·United European Gastroenterology Journal·Jurij HanželDavid Drobne
Aug 20, 2019·Clinical Pharmacology and Therapeutics·Nathalie Van den BergheDebby Thomas
Jul 29, 2019·Current Treatment Options in Gastroenterology·Saurabh Kapur, Stephen B Hanauer
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele
Aug 3, 2020·Journal of Clinical Gastroenterology·Scott D LeeEdward V Loftus
Aug 14, 2021·The American Journal of Gastroenterology·Adam S CheifetzKonstantinos Papamichael

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Erwin DreesenSéverine Vermeire
Inflammatory Bowel Diseases
Ryan S CarvalhoCarmen Cuffari
© 2022 Meta ULC. All rights reserved