VEGF concentration from plasma-activated platelets rich correlates with microvascular density and grading in canine mast cell tumour spontaneous model.

Journal of Cellular and Molecular Medicine
Rosa PatrunoGirolamo Ranieri

Abstract

Canine cutaneous mast cell tumour (CMCT) is a common cutaneous tumour in dog, with a higher incidence than in human. CMCT is classified in three subgroups, well and intermediately differentiated (G1 and G2), corresponding to a benign disease, and poorly differentiated (G3), corresponding to a malignant disease, which metastasize to lymph nodes, liver, spleen and bone marrow. In this study, we have evaluated serum (S), platelet-poor plasma (P-PP), plasma-activated platelet rich (P-APR) and cytosol vascular endothelial growth factor (VEGF) concentrations, microvascular density (MVD) and mast cell density (MCD) in a series of 86 CMCTs and we have correlated these parameters with each other, by means of ELISA detection of VEGF and immunohistochemistry. Results show that VEGF level from cytosol P-APR and MVD were significantly higher in G3 CMCTs as compared to G1 or G2 subgroups. Moreover, a significantly strong correlation among VEGF levels from P-PAR and cytosol, MVD and MCD was found in G3 subgroup. Because VEGF levels from P-APR well correlated with MVD and malignancy grade in CMCT, we suggest that VEGF might be secreted from MCs and it may be a suitable surrogate inter-species angiogenetic markers of tumour progression in CMCT....Continue Reading

References

Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·D A KesslerJ Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Sep 1, 1984·Veterinary Pathology·A K PatnaikE G MacEwen
Feb 1, 1996·Nature Medicine·J Folkman
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J Polverini
Mar 29, 2002·International Archives of Allergy and Immunology·Hans-Peter Horny, Peter Valent
May 10, 2002·The American Journal of Pathology·Friedrich WimazalPeter Valent
Jun 22, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Klas Norrby
Oct 22, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·K WertherH J Nielsen
Mar 26, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Anak IamaroonSitthichai Wanachantararak
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raja M Abdel-Majid, Jean S Marshall
Mar 9, 2004·Journal of Comparative Pathology·R PreziosiM Paltrinieri
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing CaoTheoharis C Theoharides
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sydney Ch'ngSwee T Tan
Dec 15, 2005·Journal of Surgical Oncology·Keisaku KondoMizuo Miyazaki
Jan 24, 2006·European Urology·Burcin TunaZiya Kirkali
May 9, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Melanie C WerginBarbara Kaser-Hotz
Jul 18, 2006·Current Medicinal Chemistry·Girolamo RanieriDomenico Ribatti
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anthony RuskChand Khanna
Jan 2, 2007·Veterinary Immunology and Immunopathology·Laura RebuzziPeter Valent
Feb 7, 2007·The Journal of Veterinary Medical Science·Yuka KatoShigeo Tanaka
Apr 3, 2007·Journal of Comparative Pathology·S J NewmanB W Rohrbach
Jun 15, 2007·The Journal of Small Animal Practice·J M Dobson, T J Scase
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·V L BosquiazzoE H Luque
Jul 17, 2007·American Journal of Reproductive Immunology : AJRI·Osmond J D'Cruz, Fatih M Uckun
Sep 15, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henk M W VerheulEmile E Voest
Sep 20, 2007·Leukemia·D RibattiA Vacca

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Citations

Feb 15, 2011·Journal of Veterinary Internal Medicine·C D TrippJ N Bryan
Jun 25, 2009·Journal of Cancer Research and Clinical Oncology·Ming-Huang ChenMuh-Hwa Yang
Jan 11, 2014·Critical Reviews in Oncology/hematology·Ilaria MarechGirolamo Ranieri
Jun 19, 2013·Critical Reviews in Oncology/hematology·Girolamo RanieriRaffaele Luigi Sciorsci
Mar 4, 2011·Veterinary Ophthalmology·Kenneth L AbramsSusan Elliott
Nov 7, 2015·Mediators of Inflammation·Gregor HoermannPeter Valent
Mar 29, 2016·The Veterinary Quarterly·Anna Luiza F V Assumpção, Rodrigo C da Silva
Sep 4, 2015·Biochimica Et Biophysica Acta·Saranya RaviVictor M Darley-Usmar
Dec 4, 2014·Critical Reviews in Oncology/hematology·Girolamo RanieriRaffaele Luigi Sciorsci
Sep 7, 2016·Lymphatic Research and Biology·Ahmet AkgülTansu Birinci
Nov 26, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Z H WangM Wei
Mar 26, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Miao-zhen QiuRui-hua Xu
Mar 9, 2010·Immunopharmacology and Immunotoxicology·Moisés A Franco-MolinaCristina Rodríguez-Padilla
Aug 6, 2019·Expert Opinion on Pharmacotherapy·Mariarita LaforgiaGirolamo Ranieri
Oct 31, 2018·Cancers·Diana SánchezMarcela Lizano
Feb 13, 2021·Clinical and Experimental Medicine·Domenico RibattiEnrico Crivellato
Dec 22, 2020·Topics in Companion Animal Medicine·Samanta Rios MeloJulia Maria Matera
Mar 17, 2021·Veterinary and Comparative Oncology·Jennifer Ostrand FreytagBruno Cogliati

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SPSS

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