VEGF gene variability and type 1 diabetes: evidence for a protective role

Immunogenetics
Roberto Del BoGianpaolo Zerbini

Abstract

Vascular endothelial growth factor (VEGF) is a multifunctional cytokine originally described as an angiogenic factor. A number of reports have recently demonstrated that VEGF increases pancreatic islet survival after islet transplantation by stimulating angiogenesis and improving islet revascularization. Whether VEGF can protect from the autoimmune destruction of insulin-producing beta-cells that characterizes the development of type 1 diabetes is presently unknown. To clarify this issue, we studied the association of three polymorphisms of the promoter region of VEGF with type 1 diabetes in the Italian and the Finnish populations. The polymorphisms considered [C(-2578)A, G(-1190)A, and G(-1154)A] are known to modulate in vitro and in vivo VEGF expression. We found that VEGF promoter genotypes are associated with type 1 diabetes in both populations, but with different combinations. In Italian individuals, the -2578AA and -1190AA genotypes are associated with type 1 diabetes and accelerate its onset, while in Finnish individuals, -1154GG and -1190GG protect from type 1 diabetes and delay its onset. In conclusion, because the expected functional consequence of both genotype combinations is a reduced VEGF expression in diabetic pa...Continue Reading

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Citations

Aug 19, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shinko NakamuraYasuhiko Iwamoto
Sep 7, 2006·Inflammatory Bowel Diseases·Marc FerranteSeverine Vermeire
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Mar 11, 2009·Journal of the Neurological Sciences·Roberto Del BoGiacomo Pietro Comi
Jun 19, 2007·Neurobiology of Aging·Roberto Del BoGiacomo Pietro Comi
Mar 10, 2016·Autoimmunity·Ines ZaaberSophie Visvikis-Siest
May 19, 2012·Medical Hypotheses·Zhiyong YinHaichang Wang
Jul 10, 2012·International Immunopharmacology·Pervin VuralMüjdat Uysal
Sep 26, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Michelle B PagetRichard Downing
May 26, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Maximilian KrügerJürgen Brieger

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