VEGF is indirectly associated with NO production and acutely increases in response to hyperglycaemia(1).

European Journal of Clinical Investigation
Mario SiervoLes J C Bluck

Abstract

Increased levels of vascular endothelial growth factor (VEGF) have been observed in patients with metabolic syndrome (MetS). Nitric oxide (NO) formation is reduced in MetS, but its relationship to VEGF production remains poorly defined. We evaluated the association between VEGF/NO synthesis and insulin sensitivity in obese subjects and investigated the secretory response of VEGF to an acute elevation of glucose. Seven healthy normal-weight subjects, seven obese subjects without MetS and seven obese subjects with MetS were recruited. Anthropometry, body composition and cardiometabolic functions (blood pressure, glucose, insulin, triglycerides, total cholesterol, HDL-C and VEGF) were measured, and a novel stable isotope method was used to assess in vivo rates of NO production. A frequent sampling intravenous glucose tolerance test was performed to study the dynamics of VEGF release. Fasting VEGF levels were significantly higher in the two obese groups compared to the control group (P for trend = 0·02), but the difference was not significant after adjustment for age. Vascular endothelial growth factor levels were associated with systolic blood pressure (ρ = 0·54; P = 0·01) and NO production (ρ = -0·44; P = 0·04). Vascular endothel...Continue Reading

References

Jun 1, 1979·The American Journal of Physiology·R N BergmanC Cobelli
Jun 15, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J V SilhaL J Murphy
Oct 13, 2006·Clinical and Experimental Hypertension : CHE·Timoleon VyzantiadisChrysanthos Zamboulis
Dec 5, 2006·Atherosclerosis·Kuriko KimuraKimiyoshi Arimura
Mar 25, 2008·Diabetes Research and Clinical Practice·Canan ErsoySazi Imamoglu
Sep 19, 2008·Vascular and Endovascular Surgery·Daniel M BirkRabih A Chaer
Nov 29, 2008·Rapid Communications in Mass Spectrometry : RCM·Sarah J JacksonLeslie J C Bluck
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman
Mar 17, 2010·Nature·Carolina E HagbergUlf Eriksson
Jul 24, 2010·Journal of Internal Medicine·M SiervoM Ciullo
Jun 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Mario Siervo, Blossom Stephan

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Citations

Feb 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Abdulrahman L Al-Malki

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