VEGF protein associates to neurons in remote regions following cortical infarct.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Ann M StoweRandolph J Nudo

Abstract

Vascular endothelial growth factor (VEGF) is thought to contribute to both neuroprotection and angiogenesis after stroke. While increased expression of VEGF has been demonstrated in animal models after experimental ischemia, these studies have focused almost exclusively on the infarct and peri-infarct regions. The present study investigated the association of VEGF to neurons in remote cortical areas at three days after an infarct in primary motor cortex (M1). Although these remote areas are outside of the direct influence of the ischemic injury, remote plasticity has been implicated in recovery of function. For this study, intracortical microstimulation techniques identified primary and premotor cortical areas in a non-human primate. A focal ischemic infarct was induced in the M1 hand representation, and neurons and VEGF protein were identified using immunohistochemical procedures. Stereological techniques quantitatively assessed neuronal-VEGF association in the infarct and peri-infarct regions, M1 hindlimb, M1 orofacial, and ventral premotor hand representations, as well as non-motor control regions. The results indicate that VEGF protein significantly increased association to neurons in specific remote cortical areas outside ...Continue Reading

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Citations

Nov 29, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rajiv R RatanJoseph LaManna
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Sep 27, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ann M StoweRandolph J Nudo
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dirk Matthias Hermann, Anil Zechariah
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Feb 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sterling B OrtegaAnn M Stowe
May 8, 2018·International Journal of Molecular Sciences·Samuel J Geiseler, Cecilie Morland

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Methods Mentioned

BETA
biopsy
Antibody Procedure

Software Mentioned

Stereo Investigator
Deneba
Canvas
NIH Image
JMP

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