PMID: 16507216Mar 2, 2006Paper
VEGF-targeted therapy in renal cell carcinoma: active drugs and active choices
Current Oncology Reports
Brian I Rini
Abstract
Several molecular pathways are implicated in renal cell carcinoma (RCC) pathogenesis, including von Hippel--Lindau (VHL) gene inactivation leading to vascular endothelial growth factor (VEGF) expression. Therapeutic targeting of VEGF and related pathways has been undertaken in metastatic RCC. Substantial clinical activity has been reported for multiple agents, leading to several clinical questions regarding the optimal use of these agents. The biology, clinical results, and future considerations regarding VEGF-targeted agents in RCC are presented in this article.
References
May 1, 1994·Nature Genetics·J R GnarraF M Duh
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J G HermanW M Linehan
Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G A FyfeA C Louie
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
May 1, 1997·Oncogene·Y WatanabeH F Dvorak
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·R K JainE Keshet
Sep 18, 1998·Biochimica Et Biophysica Acta·C H HeldinL Rönnstrand
Jan 23, 1999·The Journal of Clinical Investigation·L E BenjaminE Keshet
Feb 19, 1999·Lancet
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PyrhönenP L Kellokumpu-Lehtinen
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N de PaulsenS Lee
Sep 22, 2001·Endocrine-related Cancer·J F LyonsG Bollag
Feb 28, 2002·Molecular and Cellular Biology·William J HansenWilliam J Welch
Mar 21, 2003·Journal of Medicinal Chemistry·Li SunCho Tang
Jun 11, 2003·Investigational New Drugs·Robert J MotzerMichael Needle
Aug 2, 2003·The New England Journal of Medicine·James C YangSteven A Rosenberg
Aug 29, 2003·The Journal of Biological Chemistry·Lakshman GunaratnamStephen Lee
Oct 28, 2003·Investigational New Drugs·Beverly DruckerRobert Motzer
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian I RiniUNKNOWN Cancer and Leukemia Group B
Jun 25, 2004·The American Journal of Pathology·Tetsuichiro InaiDonald M McDonald
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James C Yang
Oct 7, 2004·Cancer Research·Scott M WilhelmPamela A Trail
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nancy A DawsonArif Hussain
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
❮ Previous
Next ❯
Citations
Dec 26, 2006·Pharmacogenomics·Giuseppe PasqualettiGuido Bocci
Jan 26, 2007·Expert Opinion on Biological Therapy·Dolores J Schendel
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Robert A FiglinJillian Brechbiel
Mar 21, 2008·International Journal of Cancer. Journal International Du Cancer·Matteo LandriscinaElena Ranieri
Sep 26, 2007·Journal of Immunotherapy·Sebastiano ButiRodolfo Passalacqua
Apr 17, 2013·International Journal of Oncology·Jin YangXu Li
Jul 9, 2021·Bioorganic Chemistry·Yara El-DashRasha A Hassan
❮ Previous
Next ❯
Related Concepts
Related Feeds
Arterial-Venous in Development & Disease
Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.
Related Papers
Clinical Genitourinary Cancer
Brian I Rini
Current Urology Reports
Rishi Sawhney, Fairooz Kabbinavar
Seminars in Oncology
Toni K ChoueiriBrian I Rini
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Toni K ChoueiriSabina Signoretti