PMID: 16507216Mar 2, 2006Paper

VEGF-targeted therapy in renal cell carcinoma: active drugs and active choices

Current Oncology Reports
Brian I Rini

Abstract

Several molecular pathways are implicated in renal cell carcinoma (RCC) pathogenesis, including von Hippel--Lindau (VHL) gene inactivation leading to vascular endothelial growth factor (VEGF) expression. Therapeutic targeting of VEGF and related pathways has been undertaken in metastatic RCC. Substantial clinical activity has been reported for multiple agents, leading to several clinical questions regarding the optimal use of these agents. The biology, clinical results, and future considerations regarding VEGF-targeted agents in RCC are presented in this article.

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Citations

Jan 26, 2007·Expert Opinion on Biological Therapy·Dolores J Schendel
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Robert A FiglinJillian Brechbiel
Mar 21, 2008·International Journal of Cancer. Journal International Du Cancer·Matteo LandriscinaElena Ranieri

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