VEGF/NRP-1axis promotes progression of breast cancer via enhancement of epithelial-mesenchymal transition and activation of NF-κB and β-catenin

Cancer Letters
Minna LuoXinhan Zhao

Abstract

Autocrine vascular endothelial growth factor (VEGF) can regulate the survival and progression of cancers through its various receptors. But the mechanisms and mediators for these functions are largely uncovered, especially in breast cancer. We examined the potential roles and mechanisms of VEGF/neuropilin-1 (NRP-1) axis in regulating the tumorigenesis and metastasis of breast cancer and found the expression of VEGF and NRP-1 correlated with aggressiveness of breast cancer. Knockdown of VEGF or NRP-1 inhibited the proliferation, migration and invasion, but enhanced the apoptosis of MDA-MB-231 cells. In contrast, induction of NRP-1 over-expression promoted the proliferation, migration and invasion of MCF-7 cells. VEGF or NRP-1 silencing attenuated the epithelial-mesenchymal transition (EMT) process and the activation of NF-κBp65, but enhanced GSK-3β expression in MDA-MB-231 cells while NRP-1 over-expression reversed the effects in MCF-7 cells. Treatment with hVEGF165 did not change the inhibition in NRP-1 silencing MDA-MB-231 cells, but enhanced the aggressiveness of NRP-1 over-expressing MCF-7 cells. In addition, VEGF-silencing inhibited the growth and metastasis of implanted MDA-MB-231 tumors in vivo. Our novel data suggest tha...Continue Reading

References

May 27, 2004·The American Journal of Pathology·Alexander A ParikhLee M Ellis
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Aug 18, 2004·The Journal of Clinical Investigation·Margit A HuberThomas Wirth
Oct 20, 2004·The Journal of Cell Biology·Cara J Gottardi, Barry M Gumbiner
Feb 1, 2006·Experimental Cell Research·Diane R BielenbergMichael Klagsbrun
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tse-Ming HongPan-Chyr Yang
Nov 21, 2007·Cellular Signalling·Fumi Takahashi-Yanaga, Toshiyuki Sasaguri
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
Jul 4, 2008·Nature Reviews. Cancer·Lee M Ellis, Daniel J Hicklin
Jan 21, 2009·Cancer Metastasis Reviews·Otto SchmalhoferThomas Brabletz
Feb 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anil BagriRyan J Watts
Nov 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jane YanagawaSteven M Dubinett
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Sep 3, 2010·Current Opinion in Oncology·Margaret Em Van Meter, Edward S Kim
Apr 13, 2011·Trends in Molecular Medicine·Pipsa SaharinenKari Alitalo
Nov 9, 2011·Nature Medicine·Sara M Weis, David A Cheresh
Mar 7, 2012·The Journal of Experimental Medicine·Petra HamerlikJiri Bartek
Dec 12, 2012·Drug Discovery Today·Snezana Djordjevic, Paul C Driscoll
Jan 16, 2013·Seminars in Cell & Developmental Biology·Claudio Raimondi, Christiana Ruhrberg
Aug 7, 2013·Molecular Cancer·Bastian Hoesel, Johannes A Schmid
Nov 23, 2013·Nature Reviews. Cancer·Hira Lal Goel, Arthur M Mercurio

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Citations

Nov 2, 2016·Proteomics. Clinical Applications·Yan-Ming XuAndy T Y Lau
Jun 22, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Zhong XuXiao-Jun Li
Oct 11, 2017·International Journal of Molecular Sciences·Susan CostantiniMaria Costantini
Apr 17, 2018·International Journal of Molecular Sciences·Akio ShimizuHisakazu Ogita
Apr 26, 2018·Journal of Cellular Biochemistry·Rooban B Nahomi, Ram H Nagaraj
Feb 13, 2018·Current Molecular Biology Reports·F RunaJ A Kelber
Oct 16, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Lucía Angélica Méndez-GarcíaJorge Morales-Montor
Feb 6, 2019·International Journal of Molecular Sciences·Stephan Niland, Johannes A Eble
Sep 11, 2019·Cardiovascular Research·Melanie S HulshoffGuido Krenning
Mar 30, 2019·Current Opinion in Supportive and Palliative Care·Deirdre Cronin-Fenton
Apr 19, 2017·Oncotarget·Yan-Meng Yang, Wan-Xi Yang
Dec 17, 2019·NPJ Precision Oncology·Krishnendu PalDebabrata Mukhopadhyay
May 12, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Meng XieJia-Fu Ji
Aug 10, 2017·Molecular Medicine Reports·Nunzia CaporarelloCarmelina Daniela Anfuso
Apr 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingtong LvFengguo Xu
Oct 27, 2017·Frontiers in Immunology·Sohini RoyKaustubh Datta
Sep 15, 2018·Cancer Medicine·Pratiek N MatkarHoward Leong-Poi
Jul 3, 2019·International Journal of Molecular Sciences·Mohamed Zakaria NassefDaniela Grimm
Oct 24, 2018·Nature Genetics·Jongchan KimLi Ma
Jul 18, 2020·International Journal of Molecular Sciences·Eunah Shin, Ja Seung Koo
Jun 12, 2020·Communications Biology·Cátia Rebelo de AlmeidaRita Fior
Jun 13, 2020·Frontiers in Cell and Developmental Biology·Zied BoudhraaAnne-Marie Mes-Masson
Feb 20, 2020·Molecular Biology Reports·Maryam Farzaneh BehelgardiS Mohsen Asghari
May 23, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaocong WangHebo Liu
Feb 16, 2021·Cancer Treatment and Research Communications·Satomi YogosawaKiyotsugu Yoshida
Oct 31, 2020·Cancers·Panagiotis NtellasGeorge Pentheroudakis

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