Vehicle effects on in vitro release of tiaprofenic acid from different topical formulations

Il Farmaco
Y OzsoyE Cevher

Abstract

The aim of the present study was to investigate the in vitro release properties of tiaprofenic acid (TA) from different topical vehicles. Carbopol 940 gel, chitosan gel, two types of emulsion-based ointment formulations (o/w and w/o) and hydrophilic petrolatum USP were prepared with 2% drug content. Drug release from all vehicles through a standard cellophane membrane was evaluated by using Franz-type diffusion cells. In vitro release study results showed that the diffusion coefficients of the drug from vehicles rank according to the following order: Carbopol 940 gel (D = 3.11 x 10(-7) +/- 0.54 cm(2)/s) > chitosan gel (D = 0.27 x 10(-7) +/- 0.08 cm(2)/s) > emulsion-based ointment (o/w) (D = 0.18 x 10(-7) +/- 0.05 cm(2)/s) > emulsion-based ointment (w/o) (D = 0.13 x 10(-7) +/- 0.02 cm(2)/s) > hydrophilic petrolatum USP (D = 0.02 x 10(-7) +/- 0.01 cm(2)/s). Carbopol 940 gel base showed significantly higher drug release than other vehicles (P < 0.001). These results indicated that Carbopol 940 gel base is a good candidate for the topical delivery of TA, giving significantly higher drug release than the other vehicles.

References

Oct 19, 2000·International Journal of Pharmaceutics·J HadgraftC Goosen
Jun 28, 2002·International Journal of Pharmaceutics·Siamak ParsaeeMohamad Parnianpour
Sep 19, 2002·Drug Development and Industrial Pharmacy·Ahmed M el GendyAlaa A Kassem

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Citations

Dec 1, 2010·Archives of Pharmacal Research·Alper OkyarEngin Kaptan
Jan 25, 2014·Drug Delivery·Tarun GargAmit K Goyal
Aug 23, 2008·Drug Development and Industrial Pharmacy·Ornanong S KittipongpatanaNisit Kittipongpatana
Aug 14, 2012·Journal of Pharmaceutical Sciences·Anna OlejnikIzabela Nowak
Jun 17, 2010·Pharmaceutical Development and Technology·Tarek A AhmedMohammad T H Nutan
Jun 2, 2017·Pharmaceutical Development and Technology·Rajesh KataraDipak K Majumdar
Feb 5, 2014·Chemical & Pharmaceutical Bulletin·Ayşegül BektaşYıldız Ozsoy
Jul 6, 2012·Alternatives to Laboratory Animals : ATLA·Jessica StahlManfred Kietzmann
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Małgorzata Miastkowska, Paweł Śliwa

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