PMID: 3771580Jan 1, 1986Paper

Velocities and stress levels of axisymmetric, azimuthal flow within the toroidal rotary seal of the IBM 2997 continuous flow cell separator and the implications

Journal of Biomechanics
C B Harvey, E A O'Rear

Abstract

Continuous flow blood fraction separators are used to facilitate the removal of specific blood components for donation or for certain medical procedures. Problems with one such device, the IBM 2997 Blood Processor, have been noted in a number of independent investigations. A key feature of this particular unit is a ceramic rotary seal that allows the continuous separation by centrifugation to take place. The equation of motion for flow inside a split toroid cavity within the rotary seal has been solved numerically; velocities and shear stresses found numerically compare favorably with limiting case, analytical solutions. Predicted torque values as a function of rotation rate and fluid viscosity also served as an experimental check on the validity of the mathematical findings. Comparison of calculated shear stress levels and exposure times with known thresholds for cell damage shows that platelet and leukocyte losses may indeed be caused by the seal. Suggestions are made to improve performance of the IBM Blood Processor.

References

Jul 1, 1977·Circulation Research·S P Sutera
Jan 1, 1979·Biomaterials, Medical Devices, and Artificial Organs·R D Offeman, M C Williams
Jan 1, 1975·Biophysical Journal·S P Sutera, M H Mehrjardi
Mar 1, 1972·Biophysical Journal·L B LeverettE C Lynch
Mar 2, 1968·Nature·G JudsonW Greenough
May 1, 1983·Transfusion·H BijouE P Hawkins
May 1, 1981·Transfusion·N D Kalmin, A J Grindon
Nov 1, 1981·Journal of Biomedical Materials Research·J M MonroeM C Williams

❮ Previous
Next ❯

Citations

Jul 1, 1990·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·J LindenaH M Aulmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.