Venetoclax: A new wave in hematooncology

Experimental Hematology
Jana MihalyovaRoman Hajek

Abstract

Inhibitors of antiapoptotic proteins of the BCL2 family can successfully restart the deregulated process of apoptosis in malignant cells. Whereas nonselective agents have been limited by their affinity to different BCL2 members, thus inducing excessive toxicity, the highly selective BCL2 inhibitor venetoclax (ABT-199, Venclexta™) has an acceptable safety profile. To date, it has been approved in monotherapy for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL) with 17p deletion. Extension of indications can be expected in monotherapy and in combination regimens. Sensitivity to venetoclax is not common in lymphomas, but promising outcomes have been achieved in the mantle cell lymphoma group. Venetoclax is also active in multiple myeloma patients, especially in those with translocation t(11;14), even if high-risk features such as del17p are also present. Surprisingly, positive results are being obtained in elderly acute myeloid leukemia patients, in whom inhibition of BCL2 is able to substantially increase the efficacy of low-dose cytarabine or hypomethylating agents. Here, we provide a summary of available results from clinical trials and describe a specific mechanism of action that stands behind the eff...Continue Reading

Citations

Nov 15, 2018·Expert Review of Hematology·Iuliana VaxmanMorie Gertz
Apr 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Anna Korycka-WolowiecTadeusz Robak
Sep 19, 2020·Expert Opinion on Drug Safety·Anna Korycka-WołowiecTadeusz Robak
Aug 25, 2018·Journal of Cell Science·Clara R L OudenaardenPatrick W B Derksen
Jan 29, 2019·Current Oncology Reports·Michael Tveden GundesenNiels Abildgaard
Mar 28, 2020·Palliative Care and Social Practice·Sarah Anne Bird, Kevin Boyd
Feb 6, 2020·British Journal of Haematology·Tomas Jelinek
Mar 3, 2019·Cancer Discovery·Shanmugapriya Thangavadivel, John C Byrd
Jul 1, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nir Shahar, Sarit Larisch
May 1, 2021·Journal of Personalized Medicine·Christopher Chang-Yew Leow, Michael Sze Yuan Low
Jun 28, 2021·Hematology/oncology Clinics of North America·Shanmugapriya Thangavadivel, Jennifer A Woyach
Jan 1, 2020·Exploration of Targeted Anti-tumor Therapy·Peiyi ZhangGuangrong Zheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.