Venlafaxine as single therapy associated with hypertensive encephalopathy

SpringerPlus
Bengt Edvardsson

Abstract

Hypertensive encephalopathy with the clinicoradiological entity posterior reversible encephalopathy syndrome in the setting of venlafaxine as single therapy has not been reported earlier. A 46-year-old man developed hypertensive encephalopathy associated with venlafaxine as single therapy. Magnetic resonance imaging of the brain, pre and post gadolinium, carried out on day 2, displayed an increased T2 signal in the cortex on both the T2 and FLAIR images throughout the frontal and temporal lobes and in the cerebellum. Venlafaxine therapy was stopped. The patient gradually improved and he became seizure free and the blood pressure successively became normal. A magnetic resonance imaging after six weeks displayed marked regression of the abnormalities. On follow-up after 3 months, his blood pressure had been normal and he had not had any symptoms. The prescribed antiepileptic drug was discontinued as well as antihypertensive treatment. He had not experienced any new symptoms at follow-up after one year. The patient in this report had hypertensive encephalopathy associated with venlafaxine therapy. The imaging findings are compatible with hypertensive encephalopathy/posterior reversible encephalopathy syndrome. Venlafaxine is a dru...Continue Reading

References

Aug 1, 1991·Journal of Clinical Psychopharmacology·E SchweizerK Rickels
Dec 6, 2003·The American Journal of Medicine·Rahul N Khurana, Thomas E Baudendistel

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Citations

Aug 19, 2016·Medicine·Nathalie ZappellaStephane Legriel
Mar 30, 2019·Molecular Neurobiology·Bérenger LargeauStephan Ehrmann
Aug 21, 2021·Frontiers in Cardiovascular Medicine·Anna CalviAderville Cabassi
Apr 2, 2020·Case Reports in Neurology·Muhammad Taimur MalikRamin Zand

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BETA
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