Venlafaxine in dysthymic disorder

The Journal of Clinical Psychiatry
David L DunnerC B Budech

Abstract

Dysthymic disorder is a chronic depression that is usually characterized by depression rating scale scores that are lower than those for major depressive disorder. Recent studies suggest that pharmacotherapy is quite effective in the treatment of patients with this condition and, in particular, that the newer antidepressants may be better tolerated than older tricyclic antidepressants. The purpose of this study was to investigate the use of a structurally novel antidepressant, venlafaxine, in the treatment of dysthymic disorder. Seventeen patients with dysthymic disorder were entered into the study, and 14 completed it. A psychiatric interview was used to establish diagnosis, and behavior was assessed by using the Hamilton Rating Scale for Depression (HAM-D) and the Beck Depression Inventory (BDI). Patients were seen over a 9-week period, and venlafaxine treatment proceeded on an open-label basis, from a starting dose of 18.75 mg b.i.d. to a maximum dose of 225 mg/day. Two patients discontinued early because of side effects, and 1 patient took a single dose, felt better, and did not complete the trial. Analyses of all 17 patients showed significant improvement in HAM-D and BDI scores at the end of the study. Among the completer...Continue Reading

Citations

Nov 24, 1999·Depression and Anxiety·D L DunnerE O'Connor
Jan 30, 2002·Depression and Anxiety·David L DunnerS D Friedman
Apr 27, 2004·International Clinical Psychopharmacology·David J HellersteinJoy Clark
Oct 1, 2005·International Review of Psychiatry·David L Dunner
Mar 6, 2004·Bipolar Disorders·Benjamin J D H Chun, David L Dunner
Jan 1, 2003·Expert Review of Neurotherapeutics·David L Dunner
Jul 2, 2005·Journal of Psychiatric Practice·D J Hellerstein
Dec 1, 2000·Depression and Anxiety·R N Golden, L Nicholas
Nov 10, 2004·Journal of Geriatric Psychiatry and Neurology·D P DevanandSteven P Roose
Jul 13, 2000·Molecular Psychiatry·J GriffithsH Anisman
Jun 2, 2001·Journal of Clinical Psychopharmacology·D J HellersteinM Fedak

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