Venlafaxine increases cell proliferation and regulates DISC1, PDE4B and NMDA receptor 2B expression in the hippocampus in chronic mild stress mice

European Journal of Pharmacology
Xinxin ZhangHailong Zhang

Abstract

Recent evidence has identified disrupted in schizophrenia-1 (DISC1) as an important genetic risk factor for the development of many psychiatric disorders, including major depressive disorders. In addition, studies using animal models have demonstrated that chronic stress affects hippocampal structure and function. However, the functional effects of chronic stress on DISC1 remain unknown. Using a chronic mild stress (CMS) paradigm, we investigated the effects of CMS on depressive-like behaviors, hippocampal cell proliferation, and hippocampal protein expression of DISC1, phosphodiesterase 4B (PDE4B) and N-methyl-d-aspartate receptor 2B subunit (NMDA receptor 2B), which may be involved in the regulation of DISC1 and neurogenesis. We also examined the effects and possible mechanisms of the antidepressant venlafaxine in CMS mice. CMS increased the expression of DISC1 and PDE4B. Chronic treatment with venlafaxine blocked the increases in these proteins, and also reversed the CMS-induced decrease in neurogenesis and NMDA receptor 2B protein in the hippocampus. These results suggest that DISC1 may play an important role in the etiology of depression and in the action of antidepressants.

References

Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Oct 3, 2002·Nature Reviews. Cancer·James E Darnell
Dec 19, 2002·Biological Psychiatry·Stephen M StahlRichard L Rudolph
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter V MasseyZafar I Bashir
May 7, 2005·Metabolism: Clinical and Experimental·Bruce S McEwen
May 21, 2005·Behavioural Brain Research·Stathis BekrisZeta Papadopoulou-Daifoti
Sep 28, 2005·Diabetes·Alka MalhotraUNKNOWN American Diabetes Association GENNID Study Group
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Juan M EncinasGrigori Enikolopov
Jun 27, 2006·Biological Psychiatry·Alex Dranovsky, René Hen
Jul 18, 2006·Biological Psychiatry·David J PorteousJ Kirsty Millar
Jan 24, 2007·The European Journal of Neuroscience·Claudie HooperSimon Lovestone
Jan 30, 2007·Current Opinion in Neurobiology·Shaun MackieDavid J Porteous
May 8, 2007·Neuron·Steven J ClapcoteJohn C Roder
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hannah MurdochMiles D Houslay
Sep 8, 2007·The Journal of Physiology·J Kirsty MillarDavid J Porteous
Sep 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Regina L FaulknerHwai-Jong Cheng
Sep 12, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shusuke NumataTetsuro Ohmori
Mar 24, 2009·Cell·Guo-li Ming, Hongjun Song
Feb 9, 2010·Nature Neuroscience·Akiko Hayashi-TakagiAkira Sawa
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Amy J RamseyMarc G Caron
Jul 15, 2011·The Journal of Membrane Biology·Nigar YilmazIbrahim Eren
Apr 28, 2012·Behavioural Brain Research·Shu-fang FengQing-rong Tan
Jul 18, 2012·Neurobiology of Learning and Memory·Jin Gyu HongJong Hoon Ryu
Aug 19, 2014·Journal of Neuroscience Research·Sofya AbazyanMikhail Pletnikov

❮ Previous
Next ❯

Citations

Jan 13, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alvin YangSusanne Schmid
Sep 22, 2015·Chemistry & Biology·Pia R LundegaardE Elizabeth Patton
Nov 29, 2017·BMC Complementary and Alternative Medicine·Harquin Simplice FoyetAlin Ciobica
Mar 21, 2019·Scientific Reports·Federica CavalierePierluigi Nicotera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.