Jul 10, 2002

Veno-venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods

W BehringerS Tisherman


Mild hypothermia (33-36 degrees C) might be beneficial when induced during or after insults to the brain (cardiac arrest, brain trauma, stroke), spinal cord (trauma), heart (acute myocardial infarction), or viscera (hemorrhagic shock). Reaching the target temperature rapidly in patients inside and outside hospitals remains a challenge. This study was to test the feasibility of veno-venous extracorporeal blood cooling for the rapid induction of mild hypothermia in dogs, using a simple pumping-cooling device. Ten custom-bred hunting dogs (21-28 kg) were lightly anesthetized and mechanically ventilated. In five dogs, two catheters were inserted through femoral veins, one peripheral and the other into the inferior vena cava. The catheters were connected via a coiled plastic tube as heat exchanger (15 m long, 3 mm inside diameter, 120 ml priming volume), which was immersed in an ice-water bath. A small roller-pump produced a veno-venous flow of 200 ml/min (about 10% of cardiac output). In five additional dogs (control group), a clinically practiced external cooling method was employed, using alcohol over the skin of the trunk and fanning plus ice-bags. During spontaneous normotension, veno-venous cooling delivered blood into the ven...Continue Reading

Mentioned in this Paper

Brain Injuries
Entire Vena Cava
Intravenous Drug Delivery Systems
Venous Blood Substance
Population Program Specialists
Portion of Venous Blood
Malignant Neoplasm of Spinal Cord
Myocardial Infarction
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord

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