Venocclusive disease of the liver after bone marrow transplantation: the role of hemostasis

Leukemia & Lymphoma
E M Faioni, P M Mannucci

Abstract

Venocclusive disease of the liver is a relatively frequent early complication of bone marrow transplantation related to pre-transplant toxic injury to the liver. Events that lead to toxicity of the liver in the pre-transplant setting are infection, anti-neoplastic and anti-infectious drug administration and radiation. The histological correlates of venocclusive disease are lesions mainly localized to structures in zone 3 of the liver acinus and in the sublobular central venules. At some point in the pathogenesis of venocclusive disease, blood clotting and inflammation occur. The first is characterized by laboratory signs of coagulation activation, by an increase in several procoagulant proteins and by a decrease in naturally occurring anticoagulants, particularly protein C, the latter being a sensitive index of liver injury. Inflammation is mediated by cytokine production, which maintains procoagulant endothelial responses and liver injury. Severe venocclusive disease is associated with multi-organ failure and elevated mortality. Attempts at finding predictive markers of the disease have succeeded in identifying some coagulation and inflammatory proteins which can be useful in predicting the occurrence of VOD in selected patien...Continue Reading

References

Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Y Scoazec, G Feldmann
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T AndusW Gerok
Jan 1, 1990·Annual Review of Medicine·H GerlachD M Stern
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G B McDonaldE D Thomas
Jun 1, 1995·AJR. American Journal of Roentgenology·S A TeefeyW D Middleton
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H M ShulmanG B McDonald
Sep 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S I BearmanG B McDonald
Aug 1, 1993·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·C NicolauR Vilana
Mar 1, 1993·Blood Reviews·E CarrerasC Rozman
Jun 1, 1993·Journal of the American Academy of Dermatology·N L Kao, H J Rosenblate

❮ Previous
Next ❯

Citations

Apr 12, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Salih AksuSemra V Dundar

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.