PMID: 3758146Jan 1, 1986Paper

Venoconstrictor effects of dihydroergotamine after intranasal and intramuscular administration

European Journal of Clinical Pharmacology
W H Aellig, J Rosenthaler

Abstract

A parenteral formulation of dihydroergotamine (DHE) is the only galenical form now available for the treatment of acute attacks of migraine in which a rapid onset of action is required. A recently developed nasal spray of DHE has been compared with intramuscular DHE for its venoconstrictor activity. In a randomised double-blind, cross-over trial, 9 healthy male volunteers received a single dose of DHE 1 mg intranasally, DHE 0.5 mg i.m. or placebo (intranasally and i.m.) on three different occasions, with an interval of at least 1 week between doses. Both active treatments, but not placebo, produced marked venoconstriction as shown by reduced compliance of superficial hand veins. The effect persisted for more than 8 h. The maximum venoconstrictor effect of 1 mg DHE intranasally was 40 +/- 12% (mean +/- SEM) and after 0.5 mg i.m. it was 52 +/- 15%. The time course of the venoconstrictor effect was similar after both routes of administration. Blood pressure and heart rate changes in these normotensive subjects were almost identical after dihydroergotamine and placebo. The results suggest that the nasal spray could be used as an alternative to parenteral DHE, permitting self-administration of the drug for the treatment of acute att...Continue Reading

References

Sep 1, 1985·Cephalalgia : an International Journal of Headache·P LouisC Hedman
Jan 1, 1974·European Journal of Clinical Pharmacology·W H Aellig
Jan 17, 1970·British Medical Journal·O G Brooke, B F Robinson
Mar 1, 1981·British Journal of Clinical Pharmacology·W H Aellig

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Citations

Apr 27, 2013·CNS Drugs·Stephen D Silberstein, Shashidhar H Kori
Aug 1, 1988·Immunology Letters·G PflanzB U von Specht
Jun 6, 2000·Advanced Drug Delivery Reviews·V D RomeoC R Behl
Jul 17, 2001·British Journal of Clinical Pharmacology·J N de HoonL M Van Bortel
Oct 1, 1994·British Journal of Clinical Pharmacology·W H Aellig
May 8, 2008·Cephalalgia : an International Journal of Headache·P C Tfelt-Hansen, P J Koehler
Apr 1, 2010·Headache·Eric P Baron, Stewart J Tepper
Feb 1, 2003·Headache·Stephen D Silberstein, Douglas C McCrory
Sep 1, 1996·Clinical Pharmacology and Therapeutics·H HumbertD Lavène
Oct 16, 2004·Cephalalgia : an International Journal of Headache·C-H ChouS-J Wang

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