Venom allergen 5 is Associated With Deltamethrin Resistance in Culex pipiens pallens (Diptera: Culicidae)

Journal of Medical Entomology
Yuan LvChangliang Zhu

Abstract

The mosquito, Culex pipiens pallens (L.), is an important vector of encephalitis and filariasis in northern China. The control of these mosquitoes occurs primarily via the use of pyrethroid insecticides, such as deltamethrin. The widespread and improper application of pyrethroid has resulted in the evolution of pyrethroid resistance amongst many mosquito populations, including Cx. pipiens pallens. Previous studies using high-throughput transcriptome sequencing have identified that the venom allergen 5 gene is differentially expressed between deltamethrin-susceptible and deltamethrin-resistant Cx. pipiens pallens. In this study, quantitative real-time polymerase chain reaction analyses revealed that venom allergen 5 was significantly overexpressed in adult females of both deltamethrin-resistant laboratory populations and two field populations. The transcriptional level of venom allergen 5 in the laboratory populations was elevated as the levels of deltamethrin resistance increased. Full-length cDNAs of the venom allergen 5 gene were cloned from Cx. pipiens pallens, and contained an open reading frame of 765 bp, encoding a protein with 254 amino acids. The deduced amino acid sequence shared 100% identity with the ortholog in Cule...Continue Reading

References

Apr 1, 1994·The Journal of Membrane Biology·M NobileG Prestipino
Jun 1, 1996·Experimental Brain Research·M NobileL D Possani
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·R CharlabJ M Ribeiro
Nov 4, 2000·International Archives of Allergy and Immunology·T P King, M D Spangfort
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 22, 2002·EMBO Reports·Stéphanie BlandinElena A Levashina
Aug 27, 2002·Annual Review of Entomology·Jose M C Ribeiro, Ivo M B Francischetti
Oct 5, 2002·Science·Janet HemingwayJohn Vontas
Mar 24, 2004·Trends in Genetics : TIG·Richard H Ffrench-ConstantGaelle Le Goff
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·J H F PedraBarry R Pittendrigh
Jul 10, 2004·Insect Biochemistry and Molecular Biology·Janet HemingwayHilary Ranson
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean-Philippe DavidHilary Ranson
May 10, 2005·Acta Biochimica Et Biophysica Sinica·Mao-Qing GongChang-Liang Zhu
May 23, 2006·Trends in Parasitology·Janet HemingwayBrian L Sharp
Aug 18, 2006·Annual Review of Entomology·Alan D T Barrett, Stephen Higgs
Jan 25, 2007·Insect Biochemistry and Molecular Biology·Eric CalvoJosé M C Ribeiro
Dec 12, 2007·Insect Biochemistry and Molecular Biology·Ben J MansJosé M C Ribeiro
Nov 29, 2008·BMC Genomics·Fei-Fei HuangZhong-Huai Xiang
Feb 21, 2009·Parasitology Research·Mario CanalesJosé de la Fuente
Oct 20, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·L B SilvaR N C Guedes
Sep 30, 2010·Insect Biochemistry and Molecular Biology·Shuwen WuYidong Wu
Dec 15, 2010·Journal of Virology·Linda M StyerKristen A Bernard
Jan 5, 2011·Insect Biochemistry and Molecular Biology·Nongkran LumjuanHilary Ranson
Jan 19, 2012·Environmental Health Perspectives·Henk van den BergMikhail Ejov
Apr 28, 2012·Current Opinion in Microbiology·Christian Mitri, Kenneth D Vernick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.