Venom characteristics as an indicator of hybridization between Crotalus viridis viridis and Crotalus scutulatus scutulatus in New Mexico

Toxicon : Official Journal of the International Society on Toxinology
J L Glenn, R Straight

Abstract

One hundred and thirteen venoms from 46 populations of Crotalus viridis viridis were screened by immunodiffusion for protein toxins antigenically similar to the phospholipase A2 (PLA) toxin 'Mojave toxin', using a polyclonal antibody to it's basic PLA subunit. Venom i.p. LD50 values in mice were recorded from 22 of the 46 populations. The venoms of three of 14 specimens from southwest (S.W.) New Mexico and one specimen from northern Arizona were immunologically positive by the immunodiffusion tests and produced low LD50 values (0.38-0.65 mg/kg) compared to all immunologically negative venoms (0.9-5.5 mg/kg). These four specimens were morphologically typical for C. v. viridis and their venoms were the only samples of 15 southern New Mexico specimens examined by reverse phase HPLC to exhibit peaks corresponding to the acidic and basic subunits of Mojave toxin. Alkaline polyacrylamide gel electrophoresis (PAGE) analysis of the recombined subunit peaks from the C.v. viridis venom from the S.W. New Mexico specimens showed more similarity to Mojave toxin from C.s. scutulatus venom than to similar toxins in C.v. concolor venom. The combined results of the immunodiffusion, lethal toxicity tests, HPLC profiles and PAGE analysis strongly...Continue Reading

References

Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·J L Glenn, R Straight
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Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·J L Glenn, R Straight
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Jan 1, 1981·Toxicon : Official Journal of the International Society on Toxinology·W R Pool, A L Bieber

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Citations

Jun 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·B FrancisI I Kaiser
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R C StraightM C Wolfe
Nov 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R C StraightM C Wolfe
Nov 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E D RaelJ Perez
Mar 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·J L GlennT B Wolt
Jan 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·C L OwnbyS P White
Mar 31, 2009·The American Journal of Emergency Medicine·Omid ZadTruman Milling
Oct 5, 2010·The American Journal of Emergency Medicine·Patrick CrockerElbert Whorton
Aug 9, 2016·Toxicon : Official Journal of the International Society on Toxinology·Cara Francesca Smith, Stephen P Mackessy
Feb 22, 2017·The Biochemical Journal·Juan J Calvete

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