PMID: 9191535Jun 15, 1997Paper

Venoocclusive disease of the liver after chemotherapy with vincristine, actinomycin D, and cyclophosphamide for the treatment of rhabdomyosarcoma. A report of the Intergroup Rhabdomyosarcoma Study Group. Childrens Cancer Group, the Pediatric Oncology Group, and the Pediatric Intergroup Statistical Center

Cancer
J A OrtegaH M Maurer

Abstract

Venoocclusive disease (VOD) of the liver is a common complication after allogenic and autologous bone marrow transplantation for malignant disease. The authors report the unusual and unexpected complication of VOD of the liver occurring in children with rhabdomyosarcoma who were receiving vincristine, actinomycin D, and cyclophosphamide (VAC) according to the chemotherapy regimens of the Intergroup Rhabdomyosarcoma Study (IRS) IV. The authors evaluated 821 patients with newly diagnosed rhabdomyosarcoma receiving treatment according to IRS IV who were considered at risk for VOD. Ten patients developed VOD of the liver for an overall incidence of 1.2%. VOD was found only after the administration of VAC chemotherapy. The highest incidence of VOD was observed among patients who had previously received vincristine and melphalan (Regimen 48). None of the patients receiving the chemotherapy regimen of vincristine and actinomycin D (Regimen 44) developed VOD. Patients receiving VAC-containing regimens on the IRS IV were found to be at risk for VOD. The VAC combination was used extensively in previous IRS studies (I, II, and III) and VOD was not reported during these studies, strongly suggesting that the escalation of the cyclophosphami...Continue Reading

Citations

May 30, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L D'AntigaG Mieli-Vergani
Dec 10, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Hajime Hosoi
Dec 1, 2005·Pediatric Blood & Cancer·Murat ElliSabri Acar
Jan 23, 1999·Clinical Radiology·K McHugh, A E Boothroyd
Feb 14, 2006·Seminars in Oncology·Nasir ShahabDonald C Doll
Feb 14, 2006·Seminars in Oncology·Justin FloydMichael C Perry
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ArndtW Meyer
May 24, 2005·Bone Marrow Transplantation·C C BarkerJ D Butzner
Dec 14, 2006·Therapeutic Drug Monitoring·Priska KaufmannStephan Krähenbühl
Aug 31, 2010·Paediatric Drugs·Maria Giuseppina CefaloRiccardo Riccardi
Nov 23, 2013·The American Journal of Case Reports·Mayssaa SalmanRaya Saab
Feb 16, 1999·Seminars in Surgical Oncology·A S PappoT E Lobe
Sep 1, 2018·European Journal of Clinical Pharmacology·Hannah Yejin KimAlan V Boddy
Aug 25, 2009·Journal of Neuro-oncology·M Kashif IshaqiEric Bouffet
Nov 4, 2021·Pediatric Radiology·Anneloes E BohteMaarten H Lequin

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