PMID: 16518519Mar 7, 2006Paper

Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency

Angiology
M R CesaroneM Cacchio

Abstract

The aim of this independent study was to investigate differences in efficacy between oxerutins (Venoruton) and 500 mg micronized diosmin + hesperidin (D+H) (Daflon) in patients with chronic venous insufficiency (CVI), evaluating venous-related quality of life (Ve-QOL). A first group of 90 patients with severe venous hypertension (CVI, ankle swelling) was randomized to treatment with oxerutins or D+H. The oxerutins group received oral oxerutins (2 g/day); the D+H group received 3 (500 mg) tablets daily every 8 hours for 8 weeks. A second group of 122 comparable patients was included in a registry following the same study format. The 2 treatments were administered with the same methods and procedures. Clinical conditions were comparable. All patients completing 8 weeks of treatment were included in a registry. Specialists or general practitioners included patients when they considered that clinical conditions were compatible with treatment indications using 1 of the 2 treatments on the basis of their evaluation and experience. When cases were compatible with the registry, the prescribing physician communicated the case to our monitoring center. Patients were evaluated without interfering with their treatment. The main target of e...Continue Reading

References

Jan 11, 1986·British Medical Journal·G RaymanJ E Tooke
Dec 26, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G DanielssonL Norgren

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Citations

Apr 12, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sanjay L Dholakiya, Kenza E Benzeroual
May 6, 2014·Phlebology·Isabella WernerAndres Beiras-Fernandez
Feb 10, 2018·Current Vascular Pharmacology·Djordje RadakEsma Isenovic
Sep 1, 2015·The Journal of Pharmacology and Experimental Therapeutics·Elisabeth MacColl, Raouf A Khalil
Apr 7, 2016·The Cochrane Database of Systematic Reviews·Maria José Martinez-ZapataXavier Bonfill Cosp
Jun 14, 2017·International Journal of Biological Macromolecules·Cuilin ChengLei Yao
Jul 6, 2021·Anesthesiology and Pain Medicine·Mayank ArankeIvan Urits
Apr 7, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Leelavinothan Pari, Subramani Srinivasan
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rania El-FawalMona F Mahmoud

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