Venous and arterial reflex responses to positive-pressure breathing and lower body negative pressure

Journal of Applied Physiology
J K PetersG W Mack

Abstract

We examined the relative importance of arteriolar and venous reflex responses during reductions in cardiac output provoked by conditions that increase [positive end-expiratory pressure (PEEP)] or decrease [lower body negative pressure (LBNP)] peripheral venous filling. Five healthy subjects were exposed to PEEP (10, 15, 20, and 25 cmH2O) and LBNP (-10, -15, -20, and -25 mmHg) to induce progressive but comparable reductions in right atrial transmural pressure (control to minimum): from 5.9 +/- 0.4 to 1.8 +/- 0.7 and from 6.5 +/- 0.6 to 2.0 +/- 0.2 mmHg with PEEP and LBNP, respectively. Cardiac output (impedance cardiography) fell less during PEEP than during LBNP (from 3.64 +/- 0.21 to 2.81 +/- 0.21 and from 3.39 +/- 0.21 to 2.14 +/- 0.24 l.min-1.m-2 with PEEP and LBNP, respectively), and mean arterial pressure increased. We observed sustained increases in forearm vascular resistance (i.e., forearm blood flow by venous occlusion plethysmography) and systemic vascular resistance that were greater during LBNP: from 19.7 +/- 2.91 to 27.97 +/- 5.46 and from 20.56 +/- 2.48 to 50.25 +/- 5.86 mmHg.ml-1.100 ml tissue-1.min (P < 0.05) during PEEP and LBNP, respectively. Venomotor responses (venous pressure in the hemodynamically isolated...Continue Reading

References

May 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S S CassidyR L Johnson
Feb 1, 1979·Acta Physiologica Scandinavica·H BjurstedtC M Hesser
Aug 30, 1979·The New England Journal of Medicine·A J BudaE L Alderman
Jan 1, 1976·Journal of Applied Physiology·J C DennistonR F Grover
Sep 1, 1992·The American Review of Respiratory Disease·S Nanas, S Magder
Jul 1, 1992·The American Review of Respiratory Disease·H E FesslerS Permutt
Jan 1, 1991·The American Review of Respiratory Disease·H E FesslerS Permutt
Mar 1, 1974·Circulation Research·J A Drees, C F Rothe
Jan 1, 1966·Journal of Applied Physiology·S L SamueloffJ T Shepherd
Jan 1, 1966·Journal of Applied Physiology·S L SamueloffJ T Shepherd
Jul 1, 1966·Journal of Applied Physiology·C A Gilbert, P M Stevens
Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A TripathiE R Nadel
Aug 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J J MariniJ Butler
Apr 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M R PinskyB Bromberger-Barnea
Jun 1, 1982·Critical Care Medicine·M P Grace, D M Greenbaum
Jul 1, 1953·The Journal of Physiology·R J WHITNEY
Jan 1, 1948·The American Journal of Physiology·A COURNAND, H L MOTLEY

❮ Previous
Next ❯

Citations

Mar 27, 2001·Muscle & Nerve·A R PatelT C Chelimsky
Aug 18, 2001·Journal of Applied Physiology·J Wu, G W Mack
Nov 11, 2003·Journal of Applied Physiology·Ingo FietzeVirend K Somers
Jan 10, 2006·Clinical Physiology and Functional Imaging·Martin GaretFrédéric Roche
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nikolai AljuriRichard J Cohen
Jul 3, 2020·Journal of Applied Physiology·Marije WijnbergeBart F Geerts
Mar 12, 2005·Journal of Applied Physiology·Asami KitanoTakeshi Nishiyasu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.