Venous and Arterial Thrombotic Events in Systemic Lupus Erythematosus

The Journal of Rheumatology
Andrea Hinojosa-AzaolaJorge Sanchez-Guerrero

Abstract

The incidence of thrombosis in patients with systemic lupus erythematosus (SLE) is 25 to 50-fold higher than in the general population; we aimed to define the characteristics of venous thrombotic events (VTE) and arterial thrombotic events (ATE) to identify the patients at highest risk. The study included 219 patients with recent-onset SLE. At baseline, standardized medical history and laboratory tests were done. Followup visits occurred quarterly, and information about damage accrual, comorbidities, and cardiovascular risk factors was updated annually. Main outcome was development of TE after SLE diagnosis. Thirty-five patients (16%) developed TE (27 VTE, 8 ATE) during 5.21 years of followup; incidence rate 31/1000 patient-years. Most events (57%) developed within the first year of diagnosis, and 69% were not associated with lupus anticoagulant (LAC), determined with 1 method. VTE developed earlier than ATE (2.0 vs 57.5 mos, p = 0.02). In the multivariate analysis, variables preceding VTE included cutaneous vasculitis, nephrotic syndrome, dose of prednisone, and LAC in combination with anti-RNP/Sm antibodies (p < 0.03). Patients with ATE were older (median age 44 vs 29 yrs, p = 0.04), smokers, and had hypertension, diabetes me...Continue Reading

References

Apr 1, 1987·Thrombosis Research·H Vinazzer, U Pangraz
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
May 20, 1999·The New England Journal of Medicine·R D Rosenberg, W C Aird
Jun 20, 2003·Circulation·Richard H White
Dec 14, 2004·Arthritis and Rheumatism·Sergio M A TolozaUNKNOWN LUMINA Study Group
Aug 6, 2005·Arthritis and Rheumatism·Zhaleh Shariati SarabiPaul R Fortin
Jul 27, 2006·Arthritis and Rheumatism·S BernatskyR Ramsey-Goldman
Nov 18, 2008·The Journal of Rheumatology·Juanita Romero-DíazJorge Sánchez-Guerrero
Jul 25, 2009·Journal of Thrombosis and Haemostasis : JTH·V PengoUNKNOWN Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the Interna
Dec 17, 2009·Seminars in Thrombosis and Hemostasis·Emmanuel J FavaloroGiuseppe Lippi
Nov 11, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·László MuszbekIstván Komáromi
Nov 26, 2010·American Journal of Hematology·Bernard Khor, Elizabeth M Van Cott
Nov 1, 2011·Rheumatology·Juanita Romero-DíazJorge Sánchez-Guerrero
Apr 5, 2012·American Journal of Hematology·Nicholas V JohnsonElizabeth M Van Cott
May 11, 2012·Seminars in Thrombosis and Hemostasis·Geoffrey KershawYun-Mi Nguy
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Angelo L Gaffo
Oct 9, 2014·International Journal of Rheumatic Diseases·Jasmina AhluwaliaSurjit Singh

❮ Previous
Next ❯

Citations

Apr 27, 2016·Journal of Neurosciences in Rural Practice·Jefferson W Chen
Mar 27, 2018·Arthritis Care & Research·Aleksandra AntovicMarie Holmqvist
Jul 14, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kanna ShinkawaKoji Kawakami
Dec 6, 2018·Clinical Rheumatology·María Del Carmen Zamora-MedinaJuanita Romero-Diaz
Aug 6, 2019·Frontiers in Immunology·Rustem I LitvinovJohn W Weisel
Jan 6, 2017·Rheumatology·Andreas KronbichlerUNKNOWN European Vasculitis Society
Jan 1, 2017·European Heart Journal·Milka KoupenovaJane E Freedman
Nov 19, 2020·Pediatric Rheumatology Online Journal·Hai-Bo Yan, Yu-Mei Li
Apr 26, 2021·Seminars in Arthritis and Rheumatism·Andreea C DamianLihi Eder
Jun 26, 2021·KI Reports·Ian CooleyUNKNOWN Chapel Hill Alliance Promoting Excellence in Lupus (CHAPEL) group of investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.