PMID: 6108669Jun 1, 1980Paper

Venous complications after intravenous injection of diazepam, flunitrazepam, thiopentone and etomidate

Acta Anaesthesiologica Scandinavica
K Korttila, U Aromaa

Abstract

The occurrence of phlebitis, thrombosis, and thrombophlebitis after intravenous premedication with diazepam (0.15 mg/kg) dissolved in propylene glycol (Valium) or in polyethylene glycol (Diapam) or flunitrazepam (0.0125 mg/kg), and after intravenous induction of balanced general anaesthesia with thiopentone (4.0 mg/kg) or etomidate (0.3 mg/kg) was studied on the 7th and 14th postoperative days in 115 patients undergoing short-stay varicose vein surgery. Venous complications occurred most frequently after etomidate (43% at 14 days), thiopentone (23% at 14 days), and Valium (21% at 7 days). Diapam caused fewer venous sequelae (9% at 14 days) than Valium (18% at 14 days), but the smallest number of complications were noticed after flunitrazepam (8% at 7 days and none at 14 days). Venous sequelae were more severe and more extended after thiopentone and after etomidate than those after the diazepam preparations. It is concluded that venous complications after flunitrazepam premedication were mild and infrequent and that the incidence of such complications was unacceptably high after etomidate induction.

References

Jan 1, 1976·Acta Anaesthesiologica Scandinavica·K Korttila, M Linnoila
Mar 1, 1978·British Journal of Anaesthesia·K KorttilaM Hytönen
Sep 1, 1979·British Journal of Anaesthesia·M A MattilaH Heikkinen
Aug 1, 1979·British Journal of Anaesthesia·M ZachariasS B Johnston
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Dec 1, 1976·British Journal of Anaesthesia·H SiebkeB Lind
Apr 30, 1966·Lancet·G Elfving, K Saikku
Jul 1, 1969·Anaesthesia·A B Baker
Jan 1, 1966·Acta Anaesthesiologica Scandinavica·J HästbackaP Tiitinen

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Citations

Jan 1, 1983·Canadian Anaesthetists' Society Journal·E Vatashsky, H B Aronson
Mar 1, 1997·The Journal of Emergency Medicine·J M Bergen, D C Smith
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·P M Lauven, P J Kulka
Nov 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·N B Litchfield
Sep 13, 2003·Anaesthesia·K Jenkins, A B Baker
Sep 1, 1981·Anaesthesia·J A GambleL P Briggs
Dec 1, 1981·Acta Anaesthesiologica Scandinavica·L Berggren, I Eriksson
Dec 1, 1982·Acta Anaesthesiologica Scandinavica·J Kanto, U Klotz
Sep 1, 1984·Anaesthesia·M A Mattila, M Suistomaa
Jan 1, 1984·Annales Françaises D'anesthèsie Et De Rèanimation·P O MaitreD Schwander
Jan 1, 1994·Annales Françaises D'anesthèsie Et De Rèanimation·V Banssillon
Jan 1, 1987·Annales Françaises D'anesthèsie Et De Rèanimation·J Kienlen, J du Cailar
Jun 29, 2017·Medicine·Jinfeng LiuHuacheng Zhou
Aug 3, 2020·Journal of Thrombosis and Haemostasis : JTH·Tien-Yu ChenChi-Shin Wu
Mar 22, 2019·Pharmaceutics·Bahman HomayunHyo-Jick Choi

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