PMID: 9558682Apr 29, 1998Paper

Venous dysfunction and the change of blood viscosity during head-up tilt

Pacing and Clinical Electrophysiology : PACE
Y YamanouchiF M Fouad-Tarazi

Abstract

The precise stimulus that induces vasovagal syncope is still unclear. We have previously demonstrated that the peripheral distribution of blood volume (venous pooling) is a strong predictor of tilt induced vasovagal reaction. We hypothesized that an increase in venous pooling during tilt accentuates the measured increase in blood viscosity. This hypothesis is based on the previously demonstrated increase in venous pressure and subsequent increase in transcapillary fluid transudation during tilt. The increased blood viscosity, in turn, increases vascular shear rate, which may alter the vasoconstrictive and other cardiovascular responses to decreased preload. We measured blood viscosity (supine and tilt) in 56 patients with a history of orthostatic intolerance (37 with venous pooling [VP] and 19 without venous pooling [non-VP]). VP and non-VP were separated into subgroups based on blood pressure and heart rate response to tilt. There was a positive correlation between blood viscosity and plasma aldosterone in the supine. In the group as a whole, neither supine blood viscosity nor its increase during tilt differed between VP and non-VP. However, the tilt induced increase of blood viscosity was significant only in patients with til...Continue Reading

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Citations

Mar 28, 2009·The Journal of Pediatrics·Julian M Stewart
Aug 4, 2006·Pacing and Clinical Electrophysiology : PACE·Peter Mitro, Ján Spegár
Mar 31, 2019·Physiological Reports·Kevin L KellyBruce D Johnson

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