Venous thromboembolic events in patients with COVID-19: a systematic review and meta-analysis.

Age and Ageing
Ting WuMeichun Deng

Abstract

High incidence of venous thromboembolic complications in coronavirus disease 2019 (COVID-19) patients was noted recently. This study aimed to explore the factors associated with prevalence of venous thromboembolism (VTE) in COVID-19 patients. A literature search was conducted in several online databases. Fixed effects meta-analysis was performed for the factors associated with prevalence of VTE in COVID-19 patients. A total of 39 studies were analysed in this analysis. The incidence of pulmonary embolism and VTE in severe COVID-19 patients were 17% (95% CI, 13-21%) and 42% (95% CI, 25-60%), respectively. VTE were more common among individuals with COVID-19 of advance age. Male COVID-19 patients are more likely to experience VTE. Higher levels of white blood cell (WBC; WMD = 1.34 × 109/L; 95% CI, 0.84-1.84 × 109/L), D-dimer (WMD = 4.21 μg/ml; 95% CI, 3.77-4.66 μg/ml), activated partial thromboplastin time (APTT; WMD = 2.03 s; 95% CI, 0.83-3.24 s), fibrinogen (WMD = 0.49 μg/ml; 95% CI, 0.18-0.79 g/L) and C-reactive protein (CRP; WMD = 21.89 mg/L; 95% CI, 11.44-32.34 mg/L) were commonly noted in COVID-19 patients with VTE. Patients with lower level of lymphocyte (WMD = -0.15 × 109/L; 95% CI, -0.23--0.07 × 109/L) was at high risk o...Continue Reading

References

Aug 1, 1981·American Journal of Ophthalmology·J V JesterR E Smith
Jun 22, 2006·Endocrine, Metabolic & Immune Disorders Drug Targets·F R Machado, E Silva
Sep 25, 2007·Nature Medicine·Kwang Dong KimYang-Xin Fu
May 4, 2017·Seminars in Immunopathology·Rudragouda Channappanavar, Stanley Perlman
Jan 23, 2020·Journal of Medical Virology·Yu ChenDeyin Guo
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 7, 2020·Nature Reviews. Cardiology·Ying-Ying ZhengXiang Xie
Mar 17, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Huan HanCheng-Liang Zhu
Apr 1, 2020·The New England Journal of Medicine·Muthiah VaduganathanScott D Solomon
Apr 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kai DuanXiaoming Yang
Apr 11, 2020·The New England Journal of Medicine·Jonathan GreinTimothy Flanigan
Apr 18, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Cynthia MagroJeffrey Laurence
Apr 22, 2020·The Journal of Infection·Huilan TuJifang Sheng
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network
May 7, 2020·Annals of Internal Medicine·Dominic WichmannStefan Kluge
May 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raef FadelUNKNOWN Henry Ford COVID-19 Management Task Force
May 22, 2020·The New England Journal of Medicine·Maximilian AckermannDanny Jonigk
Aug 22, 2020·JAMA : the Journal of the American Medical Association·Christoph D SpinnerUNKNOWN GS-US-540-5774 Investigators
Sep 23, 2020·BMJ Supportive & Palliative Care·Meng WangMeichun Deng

❮ Previous
Next ❯

Citations

Jul 9, 2021·Journal of the American Medical Directors Association·Anne-Laure CoudercAurélie Daumas
Aug 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Li-Yan CuiZhuo-Ming Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.