Venous thromboembolism after nephrectomy: incidence, timing and associated risk factors from a national multi-institutional database

World Journal of Urology
Brian J JordanShilajit Kundu

Abstract

To evaluate the rate of venous thromboembolism (VTE) after nephrectomy with specific focus on event timing and location (before or after hospital discharge) in order to identify modifiable risk factors and establish benchmarks for preventive interventions. Using the ACS-NSQIP database, we identified patients undergoing nephrectomy from 2006 to 2012. Patients were analyzed in two cohorts: collectively and by surgical approach [open vs. lap/robotic (MIS)]. Rates of deep vein thrombosis (DVT) and pulmonary embolus (PE) were assessed and time to each event was established in relation to discharge status. Logistic regression analysis was performed to assess association between preoperative risk factors, surgical variables, and VTE. In total, 13,208 patients met inclusion criteria. The overall rate of VTE was 1.2% (PE = 0.5% and DVT = 0.8, 0.1% DVT and PE). Using regression analysis, diabetes, dependent functional status, and longer operative time were associated with higher odds of DVT. For PE, dyspnea, disseminated cancer, and longer operative time were significant associations. The rate of VTE was higher in open surgery compared to MIS (2 vs. 0.8%, p < 0.001). Median times to DVT and PE were 8.5 and 6 days, respectively, with 53.3...Continue Reading

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Citations

Mar 12, 2019·Current Opinion in Urology·Giovanni LughezzaniAlberto Saita
Aug 25, 2018·Arab Journal of Urology·Rafael Rocha Tourinho-BarbosaRafael Sanchez-Salas
Sep 3, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Marwa S Hamza, Shaker A Mousa
Jul 3, 2019·International Journal of Vascular Medicine·Michael D DakeH Bob Smouse
Oct 15, 2020·Neurourology and Urodynamics·Christina M EscobarDominique Malacarne Pape
Jul 15, 2021·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology
Aug 15, 2021·Urology·James M Bienvenu

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