PMID: 9159235Oct 1, 1996Paper

Venous thromboembolism and cancer: a two-way clinical association

Frontiers in Bioscience : a Journal and Virtual Library
P Prandoni, Andrea Piccioli

Abstract

In recent years, a growing body of evidence has provided the convincing demonstration of a strong association between cancer and venous thromboembolism. This relationship is further supported by the risk of developing overt malignancy in patients with idiopathic venous thromboembolism. However, the cost-to-benefit ratio of an extensive diagnostic work-up aimed at identifying an occult cancer in patients with spontaneous thromboembolism still has to be demonstrated. During prolonged immobilization from any cause, and following surgical interventions, patients with cancer are at a remarkably higher risk of venous thromboembolism than patients free from malignant disorders. Standard heparin in adjusted doses or a low-molecular-weight heparin in doses commonly recommended for high risk surgical patients represent the prophylactic treatment of choice for cancer patients undergoing an extensive abdominal or pelvic intervention. Furthermore, the risk of thrombotic episodes is increased in cancer patients by chemotherapy and by the use of indwelling central venous catheters. Recent data suggest a positive benefit-to-risk ratio with the systematical use of fixed mini-dose of warfarin in both conditions. After experiencing an episode of ...Continue Reading

Citations

Feb 9, 2010·Journal of Thrombosis and Thrombolysis·Celso Arrais RodriguesPaulo M G Hoff
Aug 24, 2017·The Cochrane Database of Systematic Reviews·Lindsay RobertsonRoshan Agarwal
Dec 3, 2004·ANZ Journal of Surgery·Michael J R EdmondsMalcolm Pradhan
Dec 1, 2010·Indian Journal of Surgical Oncology·Syam VikramS Vaidyanathan
Nov 19, 2018·Journal of Thrombosis and Thrombolysis·Erin R WeedaEmmeline Tran
Sep 9, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Matthew AdessWilliam H Wehrmacher
Mar 24, 2010·AJR. American Journal of Roentgenology·Faisal KhosaDonald N Di Salvo
Aug 25, 2016·The Journal of International Medical Research·Shinya SuzukiShinichiro Saito

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