Venous thromboembolism in anti-neutrophil cytoplasmic antibody-associated vasculitis: an underlying prothrombotic condition?

Rheumatology Advances in Practice
Aleksandra AntovicIva Gunnarsson

Abstract

We investigated the incidence and potential underlying risk factors of venous thromboembolism (VTE) in patients with AAV. We assessed haemostatic disturbances and factors that might contribute to the risk of development of VTE. ANCA-positive AAV patients (n = 187) were included. Previously identified risk factors for VTE and current medication were retrieved from the medical records. We assessed haemostasis using different methods [endogenous thrombin potential (ETP), overall haemostatic potential (OHP), overall coagulation potential (OCP) and overall fibrinolysis potential (OFP)] in patients with active AAV (n = 19), inactive AAV (n = 15) and healthy controls (n = 15). Twenty-eight VTEs occurred in 24 patients over a total follow-up time of 1020 person-years. A majority of VTEs occurred within the first year after diagnosis. Old age (P < 0.01), ongoing prednisolone treatment and recent rituximab administration were more common in the VTE group (P < 0.05 for all). ETP and OHP were significantly increased and OFP significantly decreased in plasma from active compared with inactive AAV patients (P < 0.05, P < 0.01 and P < 0.05, respectively) and healthy controls (P < 0.001). We could not confirm previously reported risk factors f...Continue Reading

References

Apr 20, 2001·The New England Journal of Medicine·U Seligsohn, A Lubetsky
Apr 20, 2005·Annals of Internal Medicine·Peter A MerkelUNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
Feb 8, 2006·Arthritis and Rheumatism·Sven WeidnerHarald D Rupprecht
Aug 15, 2008·Journal of the American Society of Nephrology : JASN·David J BautzRonald J Falk
Dec 5, 2008·Annals of the Rheumatic Diseases·C MukhtyarR A Luqmani
Mar 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gavin Dreyer, Stanley Fan
Jul 22, 2010·The New England Journal of Medicine·John H StoneUNKNOWN RAVE-ITN Research Group
Sep 18, 2010·Journal of the American Society of Nephrology : JASN·Annelies E BerdenPeter Hewins
Oct 28, 2010·Seminars in Thrombosis and Hemostasis·Aleksandra Antovic
Aug 29, 2012·Current Rheumatology Reports·Rodrigo Cartin-CebaUlrich Specks
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Nov 13, 2012·Current Opinion in Rheumatology·Jason Springer, Alexandra Villa-Forte
Oct 17, 2013·The Journal of Rheumatology·Marc HilhorstJan Willem Cohen Tervaert
Apr 22, 2014·Rheumatology International·Patompong Ungprasert, Anawin Sanguankeo
Mar 26, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard A WattsLuis Felipe Flores-Suárez
Apr 18, 2015·Thrombosis Journal·Giacomo EmmiDomenico Prisco
Jun 17, 2015·Nature Reviews. Cardiology·John A Heit
Sep 15, 2015·Seminars in Arthritis and Rheumatism·J Antonio Aviña-ZubietaHyon K Choi
Mar 10, 2016·Clinical Chemistry·Armando Tripodi
Mar 20, 2020·International Journal of Laboratory Hematology·Sanja Lalic-CosicAleksandra Antovic

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
urine sediment
ELISA

Software Mentioned

VASKA
EMEA
JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved