Venous Thromboembolism in Critically Ill Medical Patients Receiving Chemoprophylaxis: A Focus on Obesity and Other Risk Factors

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Gabriel V FontaineScott C Woller

Abstract

To compare the incidence of 90-day venous thromboembolism (VTE) in obese critically ill medical patients receiving VTE chemoprophylaxis with nonobese patients of similar illness severity. We also identified other VTE risk factors. Eligible patients spent ≥24 hours in an intensive care unit between November 2007 and November 2013 and received VTE chemoprophylaxis within 48 hours of admission. The primary outcome was 90-day VTE. A total of 11 111 patients were evaluated, of which 1732 obese and 1831 nonobese patients were enrolled with mean BMIs of 38.9 ± 9.2 kg/m(2) and 24.5 ± 3.1 kg/m(2) and mean Acute Physiology and Chronic Health Evaluation II scores of 28.4 ± 11.8 and 26.6 ± 11.7, respectively. The rate of 90-day VTE for the total cohort, obese, and nonobese patients was 6.5%, 7.5%, and 5.5%, respectively. Obese patients were more likely to develop VTE compared with nonobese patients (odds ratio [OR]: 1.41; 95% confidence interval [CI]: 1.03 -1.93). Other risk factors significantly associated with 90-day VTE included prior VTE (OR: 3.93; 95% CI: 1.83-8.48), trauma with surgery in the previous 30 days (OR: 3.70; 95% CI: 1.39-9.86), central venous catheters (OR: 2.64; 95% CI: 1.87-3.72), surgery within 90 days (OR: 2.40; 95% C...Continue Reading

References

Jul 1, 1982·Critical Care Medicine·J F Cade
Jun 14, 2001·Archives of Internal Medicine·J AttiaW H Geerts
Apr 10, 2002·Critical Care Medicine·Emad H IbrahimWilliam Shannon
Jul 4, 2002·Journal of Critical Care·William GeertsEdward Etchells
Dec 12, 2003·Chest·William Geerts, Rita Selby
Dec 24, 2003·Journal of Critical Care·Jean Claude LacheradeUNKNOWN French and Canadian ICU Directors Groups
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Nov 29, 2005·Journal of Critical Care·Rakesh PatelUNKNOWN Canadian Critical Care Trials Group
Aug 25, 2007·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Donald M ArnoldDeborah J Cook
Jan 10, 2009·Thrombosis and Haemostasis·Andrew F Shorr, Mark D Williams
Mar 11, 2009·Thrombosis Research·Matthew T RondinaRobert C Pendleton
Oct 22, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Anushtup DeNarendra K Pandey
Jan 30, 2010·Critical Care Medicine·Deborah J Cook, Mark A Crowther
Jan 27, 2010·Seminars in Respiratory and Critical Care Medicine·Chee M Chan, Andrew F Shorr
Mar 23, 2011·The New England Journal of Medicine·Deborah CookNicholas E Vlahakis
Mar 26, 2011·Chest·Alex C SpyropoulosUNKNOWN IMPROVE Investigators
May 31, 2011·The Journal of Arthroplasty·UNKNOWN Intermountain Joint Replacement Center Writing Committee
Oct 4, 2011·The American Journal of Medicine·Scott C WollerC Gregory Elliott
Nov 16, 2011·Critical Care Clinics·Anne G McLeod, William Geerts
Apr 13, 2012·Lancet·Samuel Z Goldhaber, Henri Bounameaux
Feb 2, 2013·Intensive Care Medicine·Philippe VignonUNKNOWN Clinical Research in Intensive Care and Sepsis Group (CRICS Group)
Apr 26, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Charles J GlueckPing Wang
Aug 21, 2013·International Journal of Critical Illness and Injury Science·Sarah M Adriance, Claire V Murphy
Sep 21, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Trudy PendergraftGerry Oster
Feb 6, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Raman KhannaRichard H White
Apr 12, 2014·Chest·Craig M LillyIlene H Zuckerman
Aug 5, 2014·Journal of Thrombosis and Thrombolysis·Jeffrey T LalamaJacqueline R McClintic
Aug 21, 2014·Intensive Care Medicine·Pablo García-OlivaresAntonio Rivera
Sep 18, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Scott C WollerC Greg Elliott
Dec 5, 2014·Critical Care Medicine·Wendy LimUNKNOWN PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators
Feb 3, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Joel FreedmanPing Wang

❮ Previous
Next ❯

Citations

Nov 8, 2017·European Journal of Anaesthesiology·Linas VenclauskasUNKNOWN ESA VTE Guidelines Task Force
May 8, 2019·Journal of Intensive Care Medicine·Tanuwong ViarasilpaStephan A Mayer
Nov 7, 2019·The Journal of Trauma and Acute Care Surgery·Saamia ShaikhAdel Elkbuli
Oct 21, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Indra WijayaIan Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.