Abstract
Although Asian population was recognized to have a lower risk of venous thromboembolism (VTE), its increasing prevalence and incidence remain unclear in patients with malignancies. We attempted to predict VTE development using activation markers of coagulation and fibrinolysis. We enrolled patients with malignancy admitted to Tonan Hospital between April and December 2014 to receive a new-for-them chemotherapy regimen. All patients were examined for VTE by computed tomography and whole-leg compression ultrasonography before chemotherapy and three months later. We also examined plasma levels of thrombin-antithrombin complex (TAT) and plasmin α2-plasmin inhibitor complex (PIC) before chemotherapy. The cut off values of TAT and PIC were set at 2.1 ng/mL and 1.8 μg/mL, respectively. Of 97 patients, the majority (67%) had distant metastases. The most common malignancies were colorectal (26%), breast (23%), and stomach (19%) cancer. VTE was detected in 29 patients (31%); all were asymptomatic. VTE was newly developed in 12 patients in the three-month observation period, which means the incidence was 49 per 1000 person-years. Non-increased PIC with increased TAT was the only significant risk factor for both VTE prevalence and incidenc...Continue Reading
References
May 20, 1999·Yonsei Medical Journal·K S SongQ Park
Oct 24, 2002·Blood·Paolo PrandoniAntonio Girolami
Jul 20, 2007·Cancer·Nicole M KudererCharles W Francis
Oct 6, 2007·Cancer·Alok A KhoranaGary H Lyman
Jan 25, 2008·Blood·Alok A KhoranaCharles W Francis
Jun 27, 2008·Thrombosis Research·Mika OmoteTakashi Wada
Dec 20, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahito SakumaTakao Kobayashi
Mar 12, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Guido ArpaiaClaudio Cimminiello
Apr 1, 2009·Diseases of the Colon and Rectum·Mogens T StenderOle Thorlacius-Ussing
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cihan AyIngrid Pabinger
Oct 16, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N KucherH Bounameaux
Sep 11, 2010·Blood·Cihan AyIngrid Pabinger
Mar 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Apr 27, 2012·Thrombosis and Haemostasis·Yuan-Bin YuTzeng-Ji Chen
May 18, 2012·Clinical Lung Cancer·Patrizia FerroniMario Roselli
Aug 4, 2012·PLoS Medicine·Freesia HorstedMatthew J Grainge
Nov 14, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alex J WalkerMatthew J Grainge
Dec 5, 2012·Bone Marrow Transplantation·Y Kanda
Sep 10, 2013·Thrombosis Research·Seiji MadoiwaJun Mimuro
Dec 19, 2014·Journal of Intensive Care·Hidesaku Asakura
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology
Citations
May 16, 2019·Journal of Clinical Laboratory Analysis·Qian ChenWei Cui
Apr 7, 2020·International Journal of Laboratory Hematology·Chanjuan CuiWei Cui
Jan 10, 2021·Cancer Medicine·Hirotsugu KenmotsuToshiaki Takahashi
Jun 7, 2021·International Journal of Hematology·Taku NoseHironobu Minami
Jun 22, 2021·Seminars in Thrombosis and Hemostasis·Julie Brogaard Larsen, Anne-Mette Hvas