Venous thromboembolism in patients with Cushing's syndrome: need of a careful investigation of the prothrombotic risk profile.

Pituitary
S KoutroumpiCarla Scaroni

Abstract

A high incidence of venous thromboembolic (VTE) complications has been reported in Cushing's syndrome (CS), mostly post-operatively and attributable to hypercoagulability. The prevalence of symptomatic VTE was investigated retrospectively in 58 consecutive CS patients in relation to acquired and genetic thrombotic risk factors. Eight CS patients (14 %) developed VTE (group A), 3 of them related and 5 unrelated to surgery. These patients had higher urinary free cortisol (p = 0.01) and VWF levels (p = 0.02) than the 50 patients without VTE (group B), as well an increase in the hemostatically more efficient, high-molecular-weight VWF multimers (p = 0.002). Factor V Leiden and the prothrombin gene 20210A variants (the most common inherited thrombophilic defects) were more represented in group A than in group B, as was the genotype GCAG/GCAG of the VWF gene promoter, known to hyperinduce VWF upregulation under cortisol excess. All but one of the patients with VTE unrelated to surgery had at least four acquired and at least one inherited risk factor. Severe hypercortisolism and VWF levels with increased haemostatic activity are strongly associated with VTE in CS. VTE episodes unrelated to surgery are attributable to the synergistic a...Continue Reading

References

Oct 28, 1995·Lancet·D C ReesJ B Clegg
Apr 1, 1997·Journal of Endocrinological Investigation·A La BroccaA Angeli
Jun 5, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A CasonatoA Girolami
May 10, 2000·Journal of Endocrinological Investigation·L M FattiP M Mannucci
Feb 24, 2001·Lancet·M de LangeP J Grant
Jan 5, 2002·Blood·Alessandra CasonatoAntonio Girolami
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Marco BoscaroAntonio Girolami
Dec 5, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria Teresa SartoriAntonio Girolami
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·G ArnaldiM Boscaro
Jan 14, 2004·Journal of Thrombosis and Haemostasis : JTH·H CeelieH L Vos
Dec 8, 2004·Clinical Endocrinology·Tatiana ManciniGiorgio Arnaldi
Nov 24, 2005·Hematology·Frits R Rosendaal
Mar 18, 2006·Thrombosis and Haemostasis·Andrew D Blann
Mar 7, 2007·Haematologica·Cihan AyIngrid Pabinger
Dec 19, 2007·Circulation·Walter AgenoPieter W Kamphuisen
May 21, 2009·The Journal of Clinical Endocrinology and Metabolism·Bregje Van ZaaneDees P M Brandjes
Jun 23, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·John A HeitL Joseph Melton
Sep 2, 2011·The Journal of Clinical Endocrinology and Metabolism·D J F StuijverV E A Gerdes

❮ Previous
Next ❯

Citations

May 13, 2014·Clinical Endocrinology·Maria Caroline Alves CoelhoMônica R Gadelha
May 15, 2015·European Journal of Endocrinology·Maria Caroline Alves CoelhoMônica R Gadelha
Sep 1, 2015·International Journal of Pediatric Endocrinology·Sara K BartzConstantine A Stratakis
Aug 8, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elizabeth M Lamos, Kashif M Munir
May 8, 2014·European Journal of Endocrinology·M TerzoloG Reimondo
Feb 12, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Mark BittlesS Alex Rottgers
Oct 6, 2018·Current Vascular Pharmacology·Goran KoracevicMilan Djordjevic
Feb 18, 2020·Journal of the Endocrine Society·Maria Gabriela SuarezMaria Fleseriu
Jan 18, 2019·Journal of the Endocrine Society·Bruna BabicNaris Nilubol
Apr 26, 2018·Archives of Endocrinology and Metabolism·Márcio Carlos MachadoAntônio Ribeiro-Oliveira
Nov 9, 2012·Clinical Endocrinology·R van der PasR A Feelders
Apr 3, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Matthieu St-JeanFabienne Langlois
Mar 21, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Cristina Capatina, Maria Fleseriu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.