Venous thromboembolism in patients with HIV/AIDS: a case-control study.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Aima A AhonkhaiJodi B Segal

Abstract

Retrospective cohort studies of HIV-infected patients suggest an incidence of venous thromboembolism (VTE) of 1% to 2%, which is 10 times that expected among people without HIV. We investigated the prevalence of established risk factors for VTE in this population and explored novel risk factors. We conducted a case-control study using patients in the Johns Hopkins University AIDS Service cohort. We used conditional logistic regression and paired t tests to test for covariates significantly associated with VTE. We identified 160 patients with VTE diagnosed radiologically or with a clinical course consistent with VTE; 23% of the cases of VTE were diagnosed in hospitalized patients. The incidence of VTE was approximately 0.5% per patient-year. Patients with VTE and control patients did not differ by gender, but black patients were overrepresented among those with VTE (odds ratio [OR]=1.9, 95% confidence interval [CI]: 1.11 to 3.08) and patients with VTE were older than controls (mean: 39 vs. 37 years; P=0.001). Patients with VTE had lower CD4 counts (229 vs. 362 cells/mm; P<0.0001), higher HIV RNA titers (120,254 vs. 71,262 copies/mL; P=0.013), and lower hemoglobin concentrations (11.4 vs. 12.7 g/dL; P<0.0001) preceding the event ...Continue Reading

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Dec 19, 2012·Bulletin de la Société de pathologie exotique·S PessinabaS A Ba
Jan 26, 2010·Expert Opinion on Drug Safety·Michelle D Liedtke, R Chris Rathbun
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Jul 15, 2021·Radiology Case Reports·Kok Hoe ChanHamid S Shaaban
Oct 10, 2021·Current HIV/AIDS Reports·Madeline CetlinMabel Toribio

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