Abstract
The guidelines by the National Comprehensive Cancer Network and the American Society for Clinical Oncology recommend the routine use of thromboprophylaxis for patients with gastric adenocarcinoma. However, many physicians in Asian countries use venous thromboembolism (VTE) prophylaxis much less often because of the perceived lower VTE incidence in this population. To evaluate the incidence of postgastrectomy VTE in Korean patients with gastric adenocarcinoma, and to identify the complications and evaluate the efficacy and safety of VTE prevention methods. The Optimal Prophylactic Method for Venous Thromboembolism After Gastrectomy in Korean Patients (PROTECTOR) randomized clinical trial was conducted between August 1, 2011, and March 31, 2015. Patients with histologically confirmed gastric adenocarcinoma presenting to a single center (Seoul St Mary's Hospital in Seoul, South Korea) were enrolled. Patients were randomized to either an intermittent pneumatic compression (IPC)-only group or an IPC+low-molecular-weight (LMW) heparin sodium group. The data were analyzed on intention-to-treat and per protocol bases. Data analysis was performed from April 1, 2016, to October 30, 2017. Venous thromboembolism incidence was the primary o...Continue Reading
References
Jul 18, 1992·Lancet·M T NurmohamedE Briët
Aug 1, 1988·Annals of Surgery·G P Clagett, J S Reisch
May 5, 1988·The New England Journal of Medicine·R CollinsR Peto
Jan 30, 1993·Lancet·V V KakkarS Kakkar
Apr 1, 1998·Archives of Internal Medicine·M D SilversteinL J Melton
Jul 10, 2001·The British Journal of Surgery·P MismettiH Decousus
Jan 28, 2004·Annals of Surgery·Rhys J Morris, John P Woodcock
Jun 1, 2005·The Lancet Oncology·Paolo PrandoniAndrea Piccioli
Aug 1, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Debraj MukherjeeDavid C Chang
Dec 20, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahito SakumaTakao Kobayashi
Jan 16, 2009·International Journal of Surgery·Pankaj Kumar GargSunil Kumar Puri
Mar 13, 2010·Annals of Surgery·Vivian E StrongMurray F Brennan
Apr 2, 2010·Annals of Surgical Oncology·Oh JeongYoung Jin Kim
May 12, 2010·Journal of Thrombosis and Haemostasis : JTH·V V KakkarUNKNOWN CANBESURE Study Group
Jun 22, 2011·Archives of Surgery·Brian BuchbergMichael J Stamos
Feb 22, 2012·Archives of Surgery·Jessica J Rosenberg, Elliott R Haut
Nov 21, 2013·Annals of Surgery·Maria Cristina VedovatiGiancarlo Agnelli
Apr 25, 2014·Annals of Surgical Treatment and Research·Sung Ho ChoiKyo Young Song
Jul 12, 2014·Annals of Surgical Oncology·Kyo Young SongCho Hyun Park
Apr 16, 2015·Journal of Oncology Practice·Gary H LymanUNKNOWN American Society of Clinical Oncology
Sep 12, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Michael B StreiffAnita M Engh
Oct 14, 2016·The Lancet Oncology·Dominique FargeAjay Kakkar
Nov 18, 2016·BMJ Open·Sunita RehalPatrick P J Phillips
Citations
Aug 6, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nigel S KeyAnna Falanga
Feb 1, 2020·Vascular Medicine·Kaushal MajmudarUNKNOWN RIETE Investigators
Nov 30, 2018·JAMA Surgery·Zachary R McCawLee-Jen Wei
Jul 16, 2019·Medicine·Hao WangShougen Cao
Dec 4, 2019·Blood Advances·David R AndersonPhilipp Dahm
Nov 30, 2018·JAMA Surgery·Yoon Ju Jung, Kyo Young Song
Feb 12, 2021·Blood Advances·Gary H LymanPablo Alonso-Coello
Feb 28, 2021·Cancer Medicine·Wonkyo ShinHyunsoon Cho
Aug 1, 2020·The Lancet. Haematology·Nicholas D KlemenKevin Y Pei
Apr 6, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Kathleen O'ConnorKristoffel R Dumon
Apr 12, 2021·Surgical Oncology·Eun Young Kim, Kyo Young Song
Sep 8, 2019·The Lancet Oncology·Dominique FargeUNKNOWN International Initiative on Thrombosis and Cancer (ITAC) advisory panel
Jun 28, 2021·Thrombosis Research·William KnollMarc Carrier
Jul 27, 2021·International Journal of Surgery·Kai-Bo ChenJian Chen
Sep 3, 2021·Langenbeck's Archives of Surgery·Kazumitsu SuzukiKoichi Suda
Oct 9, 2021·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Mar 4, 2021·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Sachiko KaidaMasaji Tani
Dec 7, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas D KlemenBarry Hashimoto
Jan 29, 2022·The Cochrane Database of Systematic Reviews·Stavros KakkosDaniel J Reddy