Abstract
Risk assessment for venous thromboembolism (VTE) and thromboprophylaxis in those with risk factors is established in adult practice. Evidence to support efficacy and safety of this approach in adolescents is lacking. We aimed to describe thrombotic risk factors and to determine the proportion of potentially preventable events in a retrospective cohort study of adolescents with VTE. Data were collected between 2008 and 2014 from eight tertiary UK centres. Qualifying events were radiologically confirmed VTE in subjects aged 12-17 years. Central venous line-related upper venous system events were excluded. 76 cases were identified, 41 males, median age 15 years. Frequent risk factors were: reduced mobility, 45%; thrombophilia, 24%; malignancy, 20%; surgery, 18%; combined oral contraceptive pill, 12%; congenital venous anomaly, 5%. 28 (37%) had no significant underlying diagnosis and no provoking event/hospitalisation, presenting as outpatients with VTE which was considered 'unpreventable'. Of 48 where there had been opportunity for risk assessment, chemical thromboprophylaxis was not indicated in 26 and was contraindicated in 8. 14/76 (18%) had an indication to consider thromboprophylaxis and no contraindication. Of these, four ha...Continue Reading
References
Nov 20, 2001·The Journal of Pediatrics·C H van OmmenM Peters
May 4, 2002·The Journal of Trauma·Monica S VavilalaFrederick P Rivara
Apr 23, 2003·Thrombosis Research·Patricia MassicotteUNKNOWN PROTEKT Study Group
Oct 14, 2004·The Journal of Pediatrics·Paul D SteinRonald E Olson
May 4, 2005·Journal of Pediatric Surgery·Anne K TruittFrancois I Luks
Jan 6, 2006·The Journal of Trauma·Michelle C AzuThomas K Lee
May 20, 2006·Thrombosis Research·Elizabeth A Chalmers
May 1, 2008·Paediatric Anaesthesia·Philip C Jackson, Judith M Morgan
Apr 17, 2009·Thrombosis Research·Matthew CavoSarah H O'Brien
May 20, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sean D CandrilliSarah H O'Brien
Jan 13, 2010·The Journal of Trauma·Sheila J HansonPeter L Havens
May 19, 2010·Heart·Jennifer HillUNKNOWN Guideline Development Group
Apr 6, 2011·Pediatrics·Leslie RaffiniDaniela Davis
May 16, 2012·Journal of Thrombosis and Haemostasis : JTH·A A SharathkumarA Rademaker
May 19, 2012·Journal of Pediatric Surgery·Johanna R Askegard-GiesmannBrian D Kenney
Jun 8, 2012·The Journal of Trauma and Acute Care Surgery·Sheila J HansonPeter L Havens
Jul 30, 2014·The Journal of Pediatrics·Christie M AtchisonNeil A Goldenberg
May 17, 2015·Thrombosis Research·Shilpa J ArlikarNeil A Goldenberg
Citations
Jun 7, 2016·The Lancet. Haematology·Tina T Biss
Apr 28, 2018·Paediatric Anaesthesia·Judith MorganUNKNOWN Association of Paediatric Anaesthetists of Great Britain and Ireland Guidelines Working Group on Thromboprophylaxis in Child
Feb 1, 2018·British Journal of Haematology·Keith R SibsonUNKNOWN British Society for Haematology
Jan 10, 2020·Blood·Char Witmer, Leslie Raffini
Jul 2, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Matthew G PintoUNKNOWN THrombosis Epidemiology in Ill Adolescents (THEIA) Study Investigators
Jul 27, 2018·Research and Practice in Thrombosis and Haemostasis·Matteo LucianiLeonardo R Brandão
Nov 23, 2016·Case Reports in Hematology·María Eva Mingot-CastellanoLourdes Baeza-Montañez
Feb 20, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Muhammed Wahhaab SadiqBushra Moiz
Apr 2, 2021·Journal of Thrombosis and Haemostasis : JTH·C Heleen van OmmenUNKNOWN Subcommittee on Pediatric, Neonatal Thrombosis, Hemostasis
May 11, 2021·Seminars in Thrombosis and Hemostasis·Melissa WhiteNeil A Goldenberg