Venous thromboembolism occurring during adolescence

Archives of Disease in Childhood
Tina BissElizabeth Chalmers

Abstract

Risk assessment for venous thromboembolism (VTE) and thromboprophylaxis in those with risk factors is established in adult practice. Evidence to support efficacy and safety of this approach in adolescents is lacking. We aimed to describe thrombotic risk factors and to determine the proportion of potentially preventable events in a retrospective cohort study of adolescents with VTE. Data were collected between 2008 and 2014 from eight tertiary UK centres. Qualifying events were radiologically confirmed VTE in subjects aged 12-17 years. Central venous line-related upper venous system events were excluded. 76 cases were identified, 41 males, median age 15 years. Frequent risk factors were: reduced mobility, 45%; thrombophilia, 24%; malignancy, 20%; surgery, 18%; combined oral contraceptive pill, 12%; congenital venous anomaly, 5%. 28 (37%) had no significant underlying diagnosis and no provoking event/hospitalisation, presenting as outpatients with VTE which was considered 'unpreventable'. Of 48 where there had been opportunity for risk assessment, chemical thromboprophylaxis was not indicated in 26 and was contraindicated in 8. 14/76 (18%) had an indication to consider thromboprophylaxis and no contraindication. Of these, four ha...Continue Reading

References

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Citations

Jun 7, 2016·The Lancet. Haematology·Tina T Biss
Apr 28, 2018·Paediatric Anaesthesia·Judith MorganUNKNOWN Association of Paediatric Anaesthetists of Great Britain and Ireland Guidelines Working Group on Thromboprophylaxis in Child
Feb 1, 2018·British Journal of Haematology·Keith R SibsonUNKNOWN British Society for Haematology
Jan 10, 2020·Blood·Char Witmer, Leslie Raffini
Jul 2, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Matthew G PintoUNKNOWN THrombosis Epidemiology in Ill Adolescents (THEIA) Study Investigators
Jul 27, 2018·Research and Practice in Thrombosis and Haemostasis·Matteo LucianiLeonardo R Brandão
Nov 23, 2016·Case Reports in Hematology·María Eva Mingot-CastellanoLourdes Baeza-Montañez
Feb 20, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Muhammed Wahhaab SadiqBushra Moiz
Apr 2, 2021·Journal of Thrombosis and Haemostasis : JTH·C Heleen van OmmenUNKNOWN Subcommittee on Pediatric, Neonatal Thrombosis, Hemostasis
May 11, 2021·Seminars in Thrombosis and Hemostasis·Melissa WhiteNeil A Goldenberg

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