Venous thromboembolism research priorities: A scientific statement from the American Heart Association and the International Society on Thrombosis and Haemostasis

Research and Practice in Thrombosis and Haemostasis
Mary CushmanAmerican Heart Association Council on Peripheral Vascular Disease, Council on Arteriosclerosis, Thrombosis, and Vascular Bio

Abstract

Venous thromboembolism (VTE) is a major cause of morbidity and mortality. The impact of the Surgeon General's Call to Action in 2008 has been lower than expected given the public health impact of this disease. This scientific statement highlights future research priorities in VTE, developed by experts and a crowdsourcing survey across 16 scientific organizations. At the fundamental research level (T0), researchers need to identify pathobiologic causative mechanisms for the 50% of patients with unprovoked VTE and better understand mechanisms that differentiate hemostasis from thrombosis. At the human level (T1), new methods for diagnosing, treating, and preventing VTE will allow tailoring of diagnostic and therapeutic approaches to individuals. At the patient level (T2), research efforts are required to understand how foundational evidence impacts care of patients (eg, biomarkers). New treatments, such as catheter-based therapies, require further testing to identify which patients are most likely to experience benefit. At the practice level (T3), translating evidence into practice remains challenging. Areas of overuse and underuse will require evidence-based tools to improve care delivery. At the community and population level (...Continue Reading

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Citations

Feb 5, 2021·Research and Practice in Thrombosis and Haemostasis·Anette Arbjerg HøjenSimon Noble
Feb 5, 2021·Research and Practice in Thrombosis and Haemostasis·Geoffrey D Barnes, Mary Cushman
Aug 21, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·S SoudetM A Sevestre Pietri

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