Venous thromboembolism with concurrent pulmonary haemorrhage in systemic vasculitis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Erika De SousaDavid Jayne

Abstract

Pulmonary haemorrhage (PH) is a serious manifestation of systemic vasculitis with high mortality rates yet vasculitis is associated with an increased prevalence of venous thromboembolism (VTE). The concurrent presentation of severe PH and VTE poses a challenge in terms of therapeutic management. This is a retrospective case review of the clinical manifestations and response to treatment in vasculitis patients presenting with concurrent pulmonary haemorrhage and VTE (pulmonary embolism and/or deep venous thrombosis). Of 35 patients with severe PH due to systemic vasculitis, 7 (20%) had concurrent VTE. The most common cause was anti-neutrophil cytoplasm antibody-associated vasculitis, followed by anti-glomerular basement membrane disease. Vasculitis responded to conventional therapies and VTE treatment with anticoagulation was uncomplicated in five of six cases. In one case, anticoagulation precipitated the PH and another was not anticoagulated and developed recurrent VTE. All patients survived without further complications after a mean follow-up of 46 months (3-98). Concurrent VTE occurred in one-fifth of cases with severe PH due to vasculitis. Management of VTE with anticoagulation was effective but led to pulmonary haemorrhage...Continue Reading

References

Apr 20, 2005·Annals of Internal Medicine·Peter A MerkelUNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
Feb 8, 2006·Arthritis and Rheumatism·Sven WeidnerHarald D Rupprecht
Feb 24, 2006·Proceedings of the American Thoracic Society·Kevin K Brown
May 17, 2007·Medicine·Romain LazorUNKNOWN Swiss Group for Interstitial and Orphan Lung Diseases (SIOLD)
Aug 15, 2008·Journal of the American Society of Nephrology : JASN·David J BautzRonald J Falk
Dec 17, 2008·Current Opinion in Rheumatology·Gunnar TomassonPeter A Merkel
Mar 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gavin Dreyer, Stanley Fan
Aug 10, 2010·Clinics in Chest Medicine·Stephen K Frankel, David Jayne
Sep 18, 2010·Journal of the American Society of Nephrology : JASN·Annelies E BerdenPeter Hewins
Jun 16, 2011·Seminars in Respiratory and Critical Care Medicine·Alina Casian, David Jayne

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Citations

Aug 18, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Scott R Henderson, Alan D Salama
Mar 2, 2017·Annals of the American Thoracic Society·Jonathan H RaymentSharon D Dell
Aug 29, 2020·Nature Reviews. Disease Primers·A Richard KitchingRenate Kain

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