Venous tone in the developmental stages of spontaneous hypertension

Hypertension
D S MartinC W Appelt

Abstract

The initial stages of hypertension in the spontaneously hypertensive rat (SHR) are characterized by an increase in cardiac output. Venous capacitance plays an important role in the control of cardiac output. This study tested the hypothesis that venous tone is elevated in the developmental stages of spontaneous hypertension. Male SHR or normotensive Wistar-Kyoto (WKY) rats were instrumented for the measurement of arterial pressure (FAP) and intrathoracic vena caval pressure (FVP). A latex-tipped catheter was advanced into the right atrium via the jugular vein. Mean circulatory filling pressure (MCFP), an index of integrated venomotor tone, was calculated as MCFP=FVP+(FAP-FVP)/VAR. FAP and FVP were recorded after 5 seconds of right atrial balloon inflation. The venous to arterial compliance ratio (VAR) was estimated as 76 for WKY and 106 for SHR. Mean arterial pressure (MAP), heart rate, and MCFP were recorded in conscious rats of 4 to 6 and 8 to 10 weeks of age. In 4- to 6-week-old rats, both MAP and MCFP were significantly elevated in the SHR (MAP, 129+/-6 mm Hg; MCFP, 6.6+/-0.4 mm Hg) compared with the age-matched WKY (MAP, 91+/-6 mm Hg; MCFP, 5.4+/-0.4 mm Hg), whereas heart rate was not significantly different. The elevation...Continue Reading

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Citations

Sep 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Dongzhe SongCatherine C Y Pang
Jun 21, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Michele PauloLusiane Maria Bendhack
Apr 8, 2011·Journal of Human Hypertension·S GoulopoulouJ A Kanaley
Feb 24, 2001·Journal of Cardiovascular Pharmacology·R J JohnsonG D Fink
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Theodora SzaszStephanie W Watts
Dec 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hui XuGregory D Fink
Oct 5, 2010·Journal of Applied Physiology·John A SielatyckiKevin D Monahan
Jul 19, 2008·Journal of Applied Physiology·Erin P DelaneyWilliam B Farquhar
Apr 20, 2005·Hypertension·Caroline DubrocaDaniel Henrion
Feb 12, 2013·The Journal of Pharmacology and Experimental Therapeutics·Sutheera SangsiriHui Xu
Mar 23, 2002·Journal of Hypertension·Ronald J JohnsonJames J Galligan
Feb 14, 2006·Brain Research·D S MartinE M Vogel
Jun 25, 2005·Vascular Pharmacology·Alex A Pérez-RiveraJames J Galligan
Jul 19, 2008·American Journal of Hypertension·Douglas S MartinKathleen M Eyster
May 15, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert FrithiofMats Rundgren
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D S MartinJ L Williams
Feb 27, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hui XuJames J Galligan

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