Ventilation and breathing pattern during progressive hypercapnia and hypoxia after human heart-lung transplantation

The American Review of Respiratory Disease
M H SandersR L Hardesty

Abstract

The effects of human pulmonary denervation on the ventilatory responses to progressive hyperoxic hypercapnia and isocapnic hypoxia as well as the effect on resting breathing pattern were evaluated in nine female heart-lung transplant (H-LT) recipients. The results were compared to those obtained from 10 normal women of comparable age and stature. Testing was performed 2 to 37 months after H-LT (median, 7.5 months). Cardiac function was normal in all H-LT recipients. None of the patients had spirometric evidence of airway obstruction, while six had a restrictive pattern with forced vital capacities less than 80% of predicted values. Resting minute ventilation (VE), tidal volume (VT), and ventilatory drive (VT/TI) in the H-LT recipients were not significantly different from those of the normal subjects. Inspiratory time (TI), however, was significantly shorter in the H-LT patients (1.64 +/- 0.2 versus 2.09 +/- 0.13 s, p = 0.035), and resting breathing frequency (F) tended to be greater in the H-LT recipients (16.27 +/- 2.04 versus 12.82 +/- 0.53 breaths/min, p = 0.052). The overall ventilatory response to hypercapnia was reduced after H-LT (0.91 +/- 0.17 versus 1.5 +/- 0.27 L/min/mm Hg CO2, p less than 0.043), as was the F respon...Continue Reading

References

Aug 1, 1976·Journal of Applied Physiology·R W HamiltonA P Fishman
Apr 1, 1975·Journal of Applied Physiology·K WassermanR Lugliani
Jun 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J B SkatrudD G Kaiser
Jun 1, 1976·The Journal of Physiology·A S RebuckN A Saunders
Oct 1, 1974·Journal of Applied Physiology·A S RebuckL D Pengelly
Oct 1, 1974·Journal of Applied Physiology·J R RiggE J Campbell
Jun 1, 1984·Acta Anaesthesiologica Scandinavica·C Lennmarken, J B Löfström
Sep 1, 1981·Respiration Physiology·J O NilsestuenJ P Kampine
May 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M I Sheldon, J F Green
Apr 1, 1960·The Journal of Clinical Investigation·C G CAROA B DUBOIS

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Citations

Jun 1, 1993·Respiration Physiology·B GrassiP Cerretelli
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·J G PantojaM B Reid
Dec 1, 1994·The Annals of Thoracic Surgery·G D TrachiotisE P Trulock
Jun 24, 2016·High Altitude Medicine & Biology·Andrew M Luks
Aug 27, 2014·Clinics in Chest Medicine·Kelly NewtonTeofilo Lee-Chiong
Oct 23, 2002·Journal of Applied Physiology·Weiying ZhaoPaul W Davenport
Oct 17, 2002·Journal of Applied Physiology·Weiying ZhaoPaul W Davenport
Apr 11, 2009·Journal of Applied Physiology·Marc Estenne
Jul 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·F Lofaso

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